Cargando…

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

BACKGROUND: Cancer remains the leading cause of human morbidity universally. Hence, we sought to assess the in vitro antiproliferative activity of new isatin-based conjugates (5a–s) against three human cancer cell lines. METHODS: The antiproliferative activities of compounds 5a–s were evaluated in v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Wabli, Reem I, Almomen, Aliyah A, Almutairi, Maha S, Keeton, Adam B, Piazza, Gary A, Attia, Mohamed I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006853/ https://www.ncbi.nlm.nih.gov/pubmed/32099332 http://dx.doi.org/10.2147/DDDT.S227862

Ejemplares similares

Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins
por: Almutairi, Maha S, et al.
Publicado: (2019)

Synthesis, Spectroscopic Characterization and Antimicrobial Potential of Certain New Isatin-Indole Molecular Hybrids
por: Al-Wabli, Reem I., et al.
Publicado: (2017)

A Facile Synthesis and Molecular Characterization of Certain New Anti-Proliferative Indole-Based Chemical Entities
por: Al-Wabli, Reem I., et al.
Publicado: (2023)

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
por: Abdel-Aziz, Hatem A, et al.
Publicado: (2017)

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents
por: Eldehna, Wagdy M., et al.
Publicado: (2018)

Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates
por: Al-Wabli, Reem I., et al.
Publicado: (2021)

Synthesis, Spectroscopic Identification and Molecular Docking of Certain N-(2-{[2-(1H-Indol-2-ylcarbonyl) hydrazinyl](oxo)acetyl}phenyl)acetamides and N-[2-(2-{[2-(Acetylamino)phenyl](oxo)acetyl}hydrazinyl)-2-oxoethyl]-1H-indole-2-carboxamides: New Antimicrobial Agents
por: Almutairi, Maha S., et al.
Publicado: (2018)

Azide–Alkyne Cycloaddition En Route to 1H-1,2,3-Triazole-Tethered Isatin–Ferrocene, Ferrocenylmethoxy–Isatin, and Isatin–Ferrocenylchalcone Conjugates: Synthesis and Antiproliferative Evaluation
por: Singh, Amandeep, et al.
Publicado: (2018)

Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity
por: Aboul-Fadl, Tarek, et al.
Publicado: (2012)

Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates
por: Cahill, Michael M., et al.
Publicado: (2017)

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer
por: Eldehna, Wagdy M., et al.
Publicado: (2021)

Synthesis and Preliminary Antimicrobial Analysis of Isatin–Ferrocene and Isatin–Ferrocenyl Chalcone Conjugates
por: Singh, Amandeep, et al.
Publicado: (2018)

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity
por: Bonvicini, Francesca, et al.
Publicado: (2022)

Synthesis and Spectroscopic Identification of Certain Imidazole-Semicarbazone Conjugates Bearing Benzodioxole Moieties: New Antifungal Agents
por: Al-Wabli, Reem I., et al.
Publicado: (2019)

Three-Carbon Linked Dihydroartemisinin-Isatin Hybrids: Design, Synthesis and Their Antiproliferative Anticancer Activity
por: Dong, Min, et al.
Publicado: (2022)

QSAR-based rational discovery of novel substituted-4′-iminospiro[indoline-3,3′-[1,2,5]thiadiazolidinyl]-2-one 1′,1′-dioxide with potent in vitro anticancer activity
por: Khedr, Mohammed A., et al.
Publicado: (2019)

Synthesis, Enzymatic Degradation, and Polymer-Miscibility Evaluation of Nonionic Antimicrobial Hyperbranched Polyesters with Indole or Isatin Functionalities
por: Li, Xiaoya, et al.
Publicado: (2021)

A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates
por: Kaminskyy, Danylo, et al.
Publicado: (2011)

Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates
por: Ibrahim, Musab Mohamed, et al.
Publicado: (2018)

Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone
por: Ke, Shaoyong, et al.
Publicado: (2019)

Antiproliferative Effect of Indole Phytoalexins
por: Chripkova, Martina, et al.
Publicado: (2016)

β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation
por: Nisha, et al.
Publicado: (2014)

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres
por: Attia, Mohamed I., et al.
Publicado: (2017)

Novel 7-Deazapurine Incorporating Isatin Hybrid Compounds as Protein Kinase Inhibitors: Design, Synthesis, In Silico Studies, and Antiproliferative Evaluation
por: Alanazi, Mohammed M., et al.
Publicado: (2023)

Antiproliferative Activity, Multikinase Inhibition, Apoptosis- Inducing Effects and Molecular Docking of Novel Isatin–Purine Hybrids
por: Alanazi, Ashwag S., et al.
Publicado: (2023)

3D-Printing of Capsule Devices as Compartmentalization Tools for Supported Reagents in the Search of Antiproliferative Isatins
por: Malatini, Camilla, et al.
Publicado: (2023)

Synthesis, Biocidal and Antibiofilm Activities of New Isatin–Quinoline Conjugates against Multidrug-Resistant Bacterial Pathogens along with Their In Silico Screening
por: Elmongy, Elshaymaa I., et al.
Publicado: (2022)

Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities
por: Al-Wabli, Reem I, et al.
Publicado: (2019)

Synthesis, Single Crystal X-ray Analysis, and Antifungal Profiling of Certain New Oximino Ethers Bearing Imidazole Nuclei
por: Al-Wabli, Reem I., et al.
Publicado: (2017)

Synthesis and Antiproliferative Activity against Cancer Cells of Indole-Aryl-Amide Derivatives
por: Zhao, Junwei, et al.
Publicado: (2022)

Design, Synthesis, and Evaluation of Novel Indole Hybrid Chalcones and Their Antiproliferative and Antioxidant Activity
por: Kudličková, Zuzana, et al.
Publicado: (2023)

QSAR and molecular docking studies of isatin and indole derivatives as SARS 3CL(pro) inhibitors
por: Soleymani, Niousha, et al.
Publicado: (2023)

1H-1,2,3-triazole tethered isatin-ferrocene conjugates: Synthesis and in vitro antimalarial evaluation
por: Kumar, Kewal, et al.
Publicado: (2014)

Synthesis and Biological Evaluation of Sclareolide-Indole Conjugates and Their Derivatives
por: Cheng, Ying, et al.
Publicado: (2023)

Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
por: Abbas, Samir Y., et al.
Publicado: (2013)

N-Benzylisatin
por: Schutte, M., et al.
Publicado: (2012)

Synthesis, Characterization, and Antibacterial Activity of New Isatin Derivatives
por: Nain, Sumitra, et al.
Publicado: (2023)

Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors
por: Irfan, Iram, et al.
Publicado: (2022)

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines
por: Youssef, Magdy M, et al.
Publicado: (2016)

Design, Synthesis and Antiproliferative Evaluation of Bis-Indole Derivatives with a Phenyl Linker: Focus on Autophagy
por: Marianna, Budovska, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7fnf4ncpdiba2j9g7dpqd08lqu