Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series

In Japan, drug therapy for schizophrenia is characterized by high-dose antipsychotic polypharmacy, which is an uncommon approach internationally. In this study, we reduced the number of antipsychotic agents in 5 patients using the Safety Correction of High-dose Antipsychotic Polypharmacy (SCAP) meth...

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Autores principales: Kamei, Hiroyuki, Yamada, Hanae, Hatano, Masakazu, Hanya, Manako, Yamada, Shigeki, Iwata, Nakao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006980/
https://www.ncbi.nlm.nih.gov/pubmed/31958917
http://dx.doi.org/10.9758/cpn.2020.18.1.159
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author Kamei, Hiroyuki
Yamada, Hanae
Hatano, Masakazu
Hanya, Manako
Yamada, Shigeki
Iwata, Nakao
author_facet Kamei, Hiroyuki
Yamada, Hanae
Hatano, Masakazu
Hanya, Manako
Yamada, Shigeki
Iwata, Nakao
author_sort Kamei, Hiroyuki
collection PubMed
description In Japan, drug therapy for schizophrenia is characterized by high-dose antipsychotic polypharmacy, which is an uncommon approach internationally. In this study, we reduced the number of antipsychotic agents in 5 patients using the Safety Correction of High-dose Antipsychotic Polypharmacy (SCAP) method and conducted a survey regarding treatment satisfaction. The switch from polypharmacy to monotherapy was achieved in all patients. There was no deterioration in psychiatric symptoms, and adverse reactions were reduced. Three of the subjects were satisfied with the decrease in the number of antipsychotic agents and dose-reduction. These results suggest that the SCAP method is a safe and useful method that can be applied in a clinical setting.
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spelling pubmed-70069802020-02-20 Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series Kamei, Hiroyuki Yamada, Hanae Hatano, Masakazu Hanya, Manako Yamada, Shigeki Iwata, Nakao Clin Psychopharmacol Neurosci Case Report In Japan, drug therapy for schizophrenia is characterized by high-dose antipsychotic polypharmacy, which is an uncommon approach internationally. In this study, we reduced the number of antipsychotic agents in 5 patients using the Safety Correction of High-dose Antipsychotic Polypharmacy (SCAP) method and conducted a survey regarding treatment satisfaction. The switch from polypharmacy to monotherapy was achieved in all patients. There was no deterioration in psychiatric symptoms, and adverse reactions were reduced. Three of the subjects were satisfied with the decrease in the number of antipsychotic agents and dose-reduction. These results suggest that the SCAP method is a safe and useful method that can be applied in a clinical setting. Korean College of Neuropsychopharmacology 2020-02 2020-02-29 /pmc/articles/PMC7006980/ /pubmed/31958917 http://dx.doi.org/10.9758/cpn.2020.18.1.159 Text en Copyright © 2020, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kamei, Hiroyuki
Yamada, Hanae
Hatano, Masakazu
Hanya, Manako
Yamada, Shigeki
Iwata, Nakao
Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series
title Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series
title_full Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series
title_fullStr Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series
title_full_unstemmed Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series
title_short Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series
title_sort effectiveness in switching from antipsychotic polypharmacy to monotherapy in patients with schizophrenia: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006980/
https://www.ncbi.nlm.nih.gov/pubmed/31958917
http://dx.doi.org/10.9758/cpn.2020.18.1.159
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