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Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
[Image: see text] The aggregation of α-synuclein, a protein involved in neurotransmitter release at presynaptic terminals, is associated with a range of highly debilitating neurodegenerative conditions, most notably Parkinson’s disease. Intraneuronal inclusion bodies, primarily composed of α-synucle...
Autores principales: | Cascella, Roberta, Perni, Michele, Chen, Serene W., Fusco, Giuliana, Cecchi, Cristina, Vendruscolo, Michele, Chiti, Fabrizio, Dobson, Christopher M., De Simone, Alfonso |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007184/ https://www.ncbi.nlm.nih.gov/pubmed/31050886 http://dx.doi.org/10.1021/acschembio.9b00312 |
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