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Biomimetic Phosphate-Catalyzed Pictet–Spengler Reaction for the Synthesis of 1,1′-Disubstituted and Spiro-Tetrahydroisoquinoline Alkaloids

[Image: see text] Tetrahydroisoquinoline (THIQ) alkaloids are an important group of compounds that exhibit a range of bioactivities. Here, a phosphate buffer-catalyzed Pictet–Spengler reaction (PSR) using unreactive ketone substrates is described. A variety of 1,1′-disubstituted and spiro-tetrahydro...

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Detalles Bibliográficos
Autores principales:	Zhao, Jianxiong, Méndez-Sánchez, Daniel, Ward, John M., Hailes, Helen C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007230/ https://www.ncbi.nlm.nih.gov/pubmed/31095375 http://dx.doi.org/10.1021/acs.joc.9b00527

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