The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants

[Image: see text] Messenger RNA (mRNA) is a promising tool for biotherapeutics, and self-amplifying mRNA (saRNA) is particularly advantageous, because it results in abundant protein expression and production is easily scalable. While mRNA therapeutics have been shown to be highly effective in small...

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Detalles Bibliográficos
Autores principales: Blakney, Anna K., McKay, Paul F., Ibarzo Yus, Bárbara, Hunter, Judith E., Dex, Elizabeth A., Shattock, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007275/
https://www.ncbi.nlm.nih.gov/pubmed/31046232
http://dx.doi.org/10.1021/acsnano.9b01774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007275/
https://www.ncbi.nlm.nih.gov/pubmed/31046232
http://dx.doi.org/10.1021/acsnano.9b01774

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