One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation

[Image: see text] A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization–methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes...

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Autores principales: Latham, Daniel E., Polidano, Kurt, Williams, Jonathan M. J., Morrill, Louis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007281/
https://www.ncbi.nlm.nih.gov/pubmed/31536370
http://dx.doi.org/10.1021/acs.orglett.9b02900
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author Latham, Daniel E.
Polidano, Kurt
Williams, Jonathan M. J.
Morrill, Louis C.
author_facet Latham, Daniel E.
Polidano, Kurt
Williams, Jonathan M. J.
Morrill, Louis C.
author_sort Latham, Daniel E.
collection PubMed
description [Image: see text] A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization–methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization–methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield).
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spelling pubmed-70072812020-02-10 One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation Latham, Daniel E. Polidano, Kurt Williams, Jonathan M. J. Morrill, Louis C. Org Lett [Image: see text] A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization–methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization–methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield). American Chemical Society 2019-09-19 2019-10-04 /pmc/articles/PMC7007281/ /pubmed/31536370 http://dx.doi.org/10.1021/acs.orglett.9b02900 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Latham, Daniel E.
Polidano, Kurt
Williams, Jonathan M. J.
Morrill, Louis C.
One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation
title One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation
title_full One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation
title_fullStr One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation
title_full_unstemmed One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation
title_short One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation
title_sort one-pot conversion of allylic alcohols to α-methyl ketones via iron-catalyzed isomerization–methylation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007281/
https://www.ncbi.nlm.nih.gov/pubmed/31536370
http://dx.doi.org/10.1021/acs.orglett.9b02900
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