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Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response

Neutral sphingomyelinase 2 (nSMase2), the product of the sphingomyelin phosphodiesterase 3 (SMPD3) gene, catalyzes the hydrolysis of sphingomyelin to ceramide. Ceramide acts on various signaling pathways to influence cell proliferation, survival, and stress response. Altered levels of sphingolipids...

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Detalles Bibliográficos
Autores principales:	Jabalee, James, Towle, Rebecca, Lawson, James, Dickman, Christopher, Garnis, Cathie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007297/ https://www.ncbi.nlm.nih.gov/pubmed/32082486 http://dx.doi.org/10.18632/oncotarget.27458

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