Exome sequencing in schizophrenia-affected parent-offspring trios reveals risk conferred by protein-coding de novo mutations

Protein-coding de novo mutations (DNMs) are significant risk factors in many neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs has thus far has been modest. We analyzed DNMs from 1,695 SCZ affected trios and 1,077 published SCZ affected trios to better understand th...

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Detalles Bibliográficos
Autores principales: Howrigan, Daniel P., Rose, Samuel A., Samocha, Kaitlin E., Fromer, Menachem, Cerrato, Felecia, Chen, Wei J., Churchhouse, Claire, Chambert, Kimberly, Chandler, Sharon D., Daly, Mark J., Dumont, Ashley, Genovese, Giulio, Hwu, Hai-Gwo, Laird, Nan, Kosmicki, Jack A., Moran, Jennifer L., Roe, Cheryl, Singh, Tarjinder, Wang, Shi-Heng, Faraone, Stephen V., Glatt, Stephen J., McCarroll, Steven A., Tsuang, Ming, Neale, Benjamin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007385/
https://www.ncbi.nlm.nih.gov/pubmed/31932770
http://dx.doi.org/10.1038/s41593-019-0564-3

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