N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug

In our recent studies, we identified compound N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) as a broad-spectrum hybrid anticonvulsant which showed potent protection across the most important animal acute seizure models such as the maximal electroshock (MES) test, the subcutaneous pentylene...

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Detalles Bibliográficos
Autores principales: Kamiński, Krzysztof, Socała, Katarzyna, Zagaja, Mirosław, Andres-Mach, Marta, Abram, Michał, Jakubiec, Marcin, Pieróg, Mateusz, Nieoczym, Dorota, Rapacz, Anna, Gawel, Kinga, Esguerra, Camila V., Latacz, Gniewomir, Lubelska, Annamaria, Szulczyk, Bartłomiej, Szewczyk, Aleksandra, Łuszczki, Jarogniew Jacek, Wlaź, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007424/
https://www.ncbi.nlm.nih.gov/pubmed/31486023
http://dx.doi.org/10.1007/s13311-019-00773-w

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