Dysregulation of Mitochondrial Ca(2+) Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1

Muscle function is regulated by Ca(2+), which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca(2+) delivery to the mitochondrial matrix via the mitochondrial Ca(2+) uniporter, the pore of which is formed...

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Detalles Bibliográficos
Autores principales: Debattisti, Valentina, Horn, Adam, Singh, Raghavendra, Seifert, Erin L., Hogarth, Marshall W., Mazala, Davi A., Huang, Kai Ting, Horvath, Rita, Jaiswal, Jyoti K., Hajnóczky, György
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007691/
https://www.ncbi.nlm.nih.gov/pubmed/31665639
http://dx.doi.org/10.1016/j.celrep.2019.09.063

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