PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

Acute treatment with replication-stalling chemotherapeutics causes reversal of replication forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss leads to chemosensitivity. Here, we show that fork degradation is no longer detectable in BRCA1-deficient cancer cells e...

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Detalles Bibliográficos
Autores principales: Quinet, Annabel, Tirman, Stephanie, Jackson, Jessica, Šviković, Saša, Lemaçon, Delphine, Carvajal-Maldonado, Denisse, González-Acosta, Daniel, Vessoni, Alexandre T., Cybulla, Emily, Wood, Matthew, Tavis, Steven, Batista, Luis F.Z., Méndez, Juan, Sale, Julian E., Vindigni, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007862/
https://www.ncbi.nlm.nih.gov/pubmed/31676232
http://dx.doi.org/10.1016/j.molcel.2019.10.008

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