Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy

A 37-year-old woman developed deep venous thrombosis (DVT) of the left lower extremity at 8 weeks of gestation during her second pregnancy. There was no personal or family history of thrombosis. She received intravenous heparin, but heparin resistance was noted. The plasma antithrombin activity decr...

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Autores principales: Yamashita, Motoki, Komaki, Tomo, Tashiro, Kohei, Inada, Yuki, Iwata, Atsushi, Ogawa, Masahiro, Morishita, Eriko, Miura, Shin-ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008054/
https://www.ncbi.nlm.nih.gov/pubmed/31554754
http://dx.doi.org/10.2169/internalmedicine.3268-19
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author Yamashita, Motoki
Komaki, Tomo
Tashiro, Kohei
Inada, Yuki
Iwata, Atsushi
Ogawa, Masahiro
Morishita, Eriko
Miura, Shin-ichiro
author_facet Yamashita, Motoki
Komaki, Tomo
Tashiro, Kohei
Inada, Yuki
Iwata, Atsushi
Ogawa, Masahiro
Morishita, Eriko
Miura, Shin-ichiro
author_sort Yamashita, Motoki
collection PubMed
description A 37-year-old woman developed deep venous thrombosis (DVT) of the left lower extremity at 8 weeks of gestation during her second pregnancy. There was no personal or family history of thrombosis. She received intravenous heparin, but heparin resistance was noted. The plasma antithrombin activity decreased to 45% in the acute phase, and it remained low postpartum. Her mother also had low plasma antithrombin activity (46%), and genetic testing revealed a heterozygous SERPINC1 mutation. Even without a family history of thrombosis, we should suspect hereditary antithrombin deficiency in patients with initial DVT and perform thorough investigation.
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spelling pubmed-70080542020-02-10 Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy Yamashita, Motoki Komaki, Tomo Tashiro, Kohei Inada, Yuki Iwata, Atsushi Ogawa, Masahiro Morishita, Eriko Miura, Shin-ichiro Intern Med Case Report A 37-year-old woman developed deep venous thrombosis (DVT) of the left lower extremity at 8 weeks of gestation during her second pregnancy. There was no personal or family history of thrombosis. She received intravenous heparin, but heparin resistance was noted. The plasma antithrombin activity decreased to 45% in the acute phase, and it remained low postpartum. Her mother also had low plasma antithrombin activity (46%), and genetic testing revealed a heterozygous SERPINC1 mutation. Even without a family history of thrombosis, we should suspect hereditary antithrombin deficiency in patients with initial DVT and perform thorough investigation. The Japanese Society of Internal Medicine 2019-09-26 2020-01-15 /pmc/articles/PMC7008054/ /pubmed/31554754 http://dx.doi.org/10.2169/internalmedicine.3268-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamashita, Motoki
Komaki, Tomo
Tashiro, Kohei
Inada, Yuki
Iwata, Atsushi
Ogawa, Masahiro
Morishita, Eriko
Miura, Shin-ichiro
Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy
title Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy
title_full Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy
title_fullStr Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy
title_full_unstemmed Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy
title_short Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy
title_sort hereditary antithrombin deficiency presenting with deep venous thrombosis during the second pregnancy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008054/
https://www.ncbi.nlm.nih.gov/pubmed/31554754
http://dx.doi.org/10.2169/internalmedicine.3268-19
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