Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis

Opioid-induced-constipation (OIC) can be treated by naldemedine and other peripherally acting mu-opioid receptor antagonists (PAMORA) via a novel mechanism. We describe the case of a 52-year-old female outpatient who developed OIC while receiving oxycodone for pain due to cancer with multiple bone m...

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Autores principales: Ishii, Koji, Yamashita, Haruna, Yamaguchi, Midori, Komatsu, Yuya, Ryu, Emi, Morishita, Satoru, Matsuo, Kumi, Kamada, Masatsugu, Ikeda, Tsunako, Ashizawa, Kazuto, Hara, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008055/
https://www.ncbi.nlm.nih.gov/pubmed/31534081
http://dx.doi.org/10.2169/internalmedicine.3098-19
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author Ishii, Koji
Yamashita, Haruna
Yamaguchi, Midori
Komatsu, Yuya
Ryu, Emi
Morishita, Satoru
Matsuo, Kumi
Kamada, Masatsugu
Ikeda, Tsunako
Ashizawa, Kazuto
Hara, Tetsuya
author_facet Ishii, Koji
Yamashita, Haruna
Yamaguchi, Midori
Komatsu, Yuya
Ryu, Emi
Morishita, Satoru
Matsuo, Kumi
Kamada, Masatsugu
Ikeda, Tsunako
Ashizawa, Kazuto
Hara, Tetsuya
author_sort Ishii, Koji
collection PubMed
description Opioid-induced-constipation (OIC) can be treated by naldemedine and other peripherally acting mu-opioid receptor antagonists (PAMORA) via a novel mechanism. We describe the case of a 52-year-old female outpatient who developed OIC while receiving oxycodone for pain due to cancer with multiple bone metastases. Although she did not have brain metastasis, opioid withdrawal syndrome (OWS) developed after taking naldemedine orally. Her Clinical Opiate-Withdrawal Score (COWS) was 19 (moderate symptoms). However, she recovered from OWS on intravenous fentanyl and a continuous infusion of oxycodone. She did not develop OWS thereafter and was discharged two days after recovery.
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spelling pubmed-70080552020-02-10 Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis Ishii, Koji Yamashita, Haruna Yamaguchi, Midori Komatsu, Yuya Ryu, Emi Morishita, Satoru Matsuo, Kumi Kamada, Masatsugu Ikeda, Tsunako Ashizawa, Kazuto Hara, Tetsuya Intern Med Case Report Opioid-induced-constipation (OIC) can be treated by naldemedine and other peripherally acting mu-opioid receptor antagonists (PAMORA) via a novel mechanism. We describe the case of a 52-year-old female outpatient who developed OIC while receiving oxycodone for pain due to cancer with multiple bone metastases. Although she did not have brain metastasis, opioid withdrawal syndrome (OWS) developed after taking naldemedine orally. Her Clinical Opiate-Withdrawal Score (COWS) was 19 (moderate symptoms). However, she recovered from OWS on intravenous fentanyl and a continuous infusion of oxycodone. She did not develop OWS thereafter and was discharged two days after recovery. The Japanese Society of Internal Medicine 2019-09-18 2020-01-15 /pmc/articles/PMC7008055/ /pubmed/31534081 http://dx.doi.org/10.2169/internalmedicine.3098-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ishii, Koji
Yamashita, Haruna
Yamaguchi, Midori
Komatsu, Yuya
Ryu, Emi
Morishita, Satoru
Matsuo, Kumi
Kamada, Masatsugu
Ikeda, Tsunako
Ashizawa, Kazuto
Hara, Tetsuya
Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis
title Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis
title_full Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis
title_fullStr Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis
title_full_unstemmed Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis
title_short Naldemedine-induced Opioid Withdrawal Syndrome in a Patient with Breast Cancer without Brain Metastasis
title_sort naldemedine-induced opioid withdrawal syndrome in a patient with breast cancer without brain metastasis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008055/
https://www.ncbi.nlm.nih.gov/pubmed/31534081
http://dx.doi.org/10.2169/internalmedicine.3098-19
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