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Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors (7a...

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Detalles Bibliográficos
Autores principales:	Al-Sanea, Mohammad M, Gotina, Lizaveta, Mohamed, Mamdouh FA, Grace Thomas Parambi, Della, Gomaa, Hesham A M, Mathew, Bijo, Youssif, Bahaa G M, Alharbi, Khalid Saad, Elsayed, Zainab M, Abdelgawad, Mohamed A, Eldehna, Wagdy M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008064/ https://www.ncbi.nlm.nih.gov/pubmed/32103894 http://dx.doi.org/10.2147/DDDT.S237957

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