PROTACs– a game-changing technology

INTRODUCTION: Proteolysis – targeting chimeras (PROTACs) have emerged as a new modality with the potential to revolutionize drug discovery. PROTACs are heterobifunctional molecules comprising of a ligand targeting a protein of interest, a ligand targeting an E3 ligase and a connecting linker. The ai...

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Detalles Bibliográficos
Autores principales: Konstantinidou, Markella, Li, Jingyao, Zhang, Bidong, Wang, Zefeng, Shaabani, Shabnam, Brake, Frans Ter, Essa, Khaled, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008130/
https://www.ncbi.nlm.nih.gov/pubmed/31538491
http://dx.doi.org/10.1080/17460441.2019.1659242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008130/
https://www.ncbi.nlm.nih.gov/pubmed/31538491
http://dx.doi.org/10.1080/17460441.2019.1659242

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