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Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review

BACKGROUND: Microemulsions drug delivery systems (MDDS) have been known to increase the bioavailability of hydrophobic drugs. The main challenge of the MDDS is the development of an effective and safe system for drug carriage and delivery. Biosurfactants are preferred surface-active molecules becaus...

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Autores principales: Ohadi, Mandana, Shahravan, Arash, Dehghannoudeh, Negar, Eslaminejad, Touba, Banat, Ibrahim M, Dehghannoudeh, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008186/
https://www.ncbi.nlm.nih.gov/pubmed/32103896
http://dx.doi.org/10.2147/DDDT.S232325
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author Ohadi, Mandana
Shahravan, Arash
Dehghannoudeh, Negar
Eslaminejad, Touba
Banat, Ibrahim M
Dehghannoudeh, Gholamreza
author_facet Ohadi, Mandana
Shahravan, Arash
Dehghannoudeh, Negar
Eslaminejad, Touba
Banat, Ibrahim M
Dehghannoudeh, Gholamreza
author_sort Ohadi, Mandana
collection PubMed
description BACKGROUND: Microemulsions drug delivery systems (MDDS) have been known to increase the bioavailability of hydrophobic drugs. The main challenge of the MDDS is the development of an effective and safe system for drug carriage and delivery. Biosurfactants are preferred surface-active molecules because of their lower toxicity and safe characteristics when compared to synthetic surfactants. Glycolipid and lipopeptide are the most common biosurfactants that were tested for MDDS. The main goal of the present systematic review was to estimate the available evidence on the role of biosurfactant in the development of MDDS. SEARCH STRATEGY: Literature searches involved the main scientific databases and were focused on the period from 2005 until 2017. The Search filter composed of two items: “Biosurfactant” and/or “Microemulsion.” INCLUSION CRITERIA: Twenty-four studies evaluating the use of biosurfactant in MDDS were eligible for inclusion. Among these 14 were related to the use of glycolipid biosurfactants in the MDDS formulations, while four reported using lipopeptide biosurfactants and six other related review articles. RESULTS: According to the output study parameters, biosurfactants acted as active stabilizers, hydrophilic or hydrophobic linkers and safety carriers in MDDS, and among them glycolipid biosurfactants had the most application in MDDS formulations. CONCLUSION: Synthetic surfactants could be replaced by biosurfactants as an effective bio-source for MDDS due to their excellent self-assembling and emulsifying activity properties.
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spelling pubmed-70081862020-02-26 Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review Ohadi, Mandana Shahravan, Arash Dehghannoudeh, Negar Eslaminejad, Touba Banat, Ibrahim M Dehghannoudeh, Gholamreza Drug Des Devel Ther Review BACKGROUND: Microemulsions drug delivery systems (MDDS) have been known to increase the bioavailability of hydrophobic drugs. The main challenge of the MDDS is the development of an effective and safe system for drug carriage and delivery. Biosurfactants are preferred surface-active molecules because of their lower toxicity and safe characteristics when compared to synthetic surfactants. Glycolipid and lipopeptide are the most common biosurfactants that were tested for MDDS. The main goal of the present systematic review was to estimate the available evidence on the role of biosurfactant in the development of MDDS. SEARCH STRATEGY: Literature searches involved the main scientific databases and were focused on the period from 2005 until 2017. The Search filter composed of two items: “Biosurfactant” and/or “Microemulsion.” INCLUSION CRITERIA: Twenty-four studies evaluating the use of biosurfactant in MDDS were eligible for inclusion. Among these 14 were related to the use of glycolipid biosurfactants in the MDDS formulations, while four reported using lipopeptide biosurfactants and six other related review articles. RESULTS: According to the output study parameters, biosurfactants acted as active stabilizers, hydrophilic or hydrophobic linkers and safety carriers in MDDS, and among them glycolipid biosurfactants had the most application in MDDS formulations. CONCLUSION: Synthetic surfactants could be replaced by biosurfactants as an effective bio-source for MDDS due to their excellent self-assembling and emulsifying activity properties. Dove 2020-02-05 /pmc/articles/PMC7008186/ /pubmed/32103896 http://dx.doi.org/10.2147/DDDT.S232325 Text en © 2020 Ohadi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Ohadi, Mandana
Shahravan, Arash
Dehghannoudeh, Negar
Eslaminejad, Touba
Banat, Ibrahim M
Dehghannoudeh, Gholamreza
Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review
title Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review
title_full Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review
title_fullStr Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review
title_full_unstemmed Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review
title_short Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review
title_sort potential use of microbial surfactant in microemulsion drug delivery system: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008186/
https://www.ncbi.nlm.nih.gov/pubmed/32103896
http://dx.doi.org/10.2147/DDDT.S232325
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