Angiomatous hyperplasia in the heart of a young rat

This case report describes angiomatous hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study. Histologically, the lesion was characterized by blood-filled vascular channels of variable diameter lined by a thin wall and surrounded by a...

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Detalles Bibliográficos
Autores principales: Piccicuto, Virginie, Dincer, Zuhal, Walker, Suzanne, Gray, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008203/
https://www.ncbi.nlm.nih.gov/pubmed/32051663
http://dx.doi.org/10.1293/tox.2019-0059
Descripción
Sumario:This case report describes angiomatous hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study. Histologically, the lesion was characterized by blood-filled vascular channels of variable diameter lined by a thin wall and surrounded by a thin fibrous stroma and minimal lympho-plasmacytic and neutrophilic infiltrate in the apex of the heart. Immunohistopathology using CD31 confirmed the blood vessel origin, and using Ki67 confirmed low cell-proliferative activity in the vascular endothelial cells. To the authors’ knowledge, this is the first report of spontaneous angiomatous hyperplasia in the heart of a young rat.

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