Angiomatous hyperplasia in the heart of a young rat

This case report describes angiomatous hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study. Histologically, the lesion was characterized by blood-filled vascular channels of variable diameter lined by a thin wall and surrounded by a...

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Autores principales: Piccicuto, Virginie, Dincer, Zuhal, Walker, Suzanne, Gray, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008203/
https://www.ncbi.nlm.nih.gov/pubmed/32051663
http://dx.doi.org/10.1293/tox.2019-0059
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author Piccicuto, Virginie
Dincer, Zuhal
Walker, Suzanne
Gray, Christopher
author_facet Piccicuto, Virginie
Dincer, Zuhal
Walker, Suzanne
Gray, Christopher
author_sort Piccicuto, Virginie
collection PubMed
description This case report describes angiomatous hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study. Histologically, the lesion was characterized by blood-filled vascular channels of variable diameter lined by a thin wall and surrounded by a thin fibrous stroma and minimal lympho-plasmacytic and neutrophilic infiltrate in the apex of the heart. Immunohistopathology using CD31 confirmed the blood vessel origin, and using Ki67 confirmed low cell-proliferative activity in the vascular endothelial cells. To the authors’ knowledge, this is the first report of spontaneous angiomatous hyperplasia in the heart of a young rat.
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spelling pubmed-70082032020-02-12 Angiomatous hyperplasia in the heart of a young rat Piccicuto, Virginie Dincer, Zuhal Walker, Suzanne Gray, Christopher J Toxicol Pathol Case Report This case report describes angiomatous hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study. Histologically, the lesion was characterized by blood-filled vascular channels of variable diameter lined by a thin wall and surrounded by a thin fibrous stroma and minimal lympho-plasmacytic and neutrophilic infiltrate in the apex of the heart. Immunohistopathology using CD31 confirmed the blood vessel origin, and using Ki67 confirmed low cell-proliferative activity in the vascular endothelial cells. To the authors’ knowledge, this is the first report of spontaneous angiomatous hyperplasia in the heart of a young rat. Japanese Society of Toxicologic Pathology 2019-12-05 2020-01 /pmc/articles/PMC7008203/ /pubmed/32051663 http://dx.doi.org/10.1293/tox.2019-0059 Text en ©2020 The Japanese Society of Toxicologic Pathology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/）.
spellingShingle Case Report
Piccicuto, Virginie
Dincer, Zuhal
Walker, Suzanne
Gray, Christopher
Angiomatous hyperplasia in the heart of a young rat
title Angiomatous hyperplasia in the heart of a young rat
title_full Angiomatous hyperplasia in the heart of a young rat
title_fullStr Angiomatous hyperplasia in the heart of a young rat
title_full_unstemmed Angiomatous hyperplasia in the heart of a young rat
title_short Angiomatous hyperplasia in the heart of a young rat
title_sort angiomatous hyperplasia in the heart of a young rat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008203/
https://www.ncbi.nlm.nih.gov/pubmed/32051663
http://dx.doi.org/10.1293/tox.2019-0059
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AT dincerzuhal angiomatoushyperplasiaintheheartofayoungrat
AT walkersuzanne angiomatoushyperplasiaintheheartofayoungrat
AT graychristopher angiomatoushyperplasiaintheheartofayoungrat

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