Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient

We report a case of fulminant Acanthamoeba castellanii encephalitis in a patient with chronic lymphocytic leukemia treated with ibrutinib. The unusually rapid neurologic decline and fatal outcome observed are probably related to alterations in immunologic function associated with inhibition of Bruto...

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Detalles Bibliográficos
Autores principales: Crothers, Jessica W, Hsu, Liangge, Marty, Francisco M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008473/
https://www.ncbi.nlm.nih.gov/pubmed/32055639
http://dx.doi.org/10.1093/ofid/ofaa025
Descripción
Sumario:We report a case of fulminant Acanthamoeba castellanii encephalitis in a patient with chronic lymphocytic leukemia treated with ibrutinib. The unusually rapid neurologic decline and fatal outcome observed are probably related to alterations in immunologic function associated with inhibition of Bruton tyrosine kinase.

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