Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient

We report a case of fulminant Acanthamoeba castellanii encephalitis in a patient with chronic lymphocytic leukemia treated with ibrutinib. The unusually rapid neurologic decline and fatal outcome observed are probably related to alterations in immunologic function associated with inhibition of Bruto...

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Detalles Bibliográficos
Autores principales: Crothers, Jessica W, Hsu, Liangge, Marty, Francisco M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008473/
https://www.ncbi.nlm.nih.gov/pubmed/32055639
http://dx.doi.org/10.1093/ofid/ofaa025
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author Crothers, Jessica W
Hsu, Liangge
Marty, Francisco M
author_facet Crothers, Jessica W
Hsu, Liangge
Marty, Francisco M
author_sort Crothers, Jessica W
collection PubMed
description We report a case of fulminant Acanthamoeba castellanii encephalitis in a patient with chronic lymphocytic leukemia treated with ibrutinib. The unusually rapid neurologic decline and fatal outcome observed are probably related to alterations in immunologic function associated with inhibition of Bruton tyrosine kinase.
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spelling pubmed-70084732020-02-13 Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient Crothers, Jessica W Hsu, Liangge Marty, Francisco M Open Forum Infect Dis Brief Report We report a case of fulminant Acanthamoeba castellanii encephalitis in a patient with chronic lymphocytic leukemia treated with ibrutinib. The unusually rapid neurologic decline and fatal outcome observed are probably related to alterations in immunologic function associated with inhibition of Bruton tyrosine kinase. Oxford University Press 2020-01-20 /pmc/articles/PMC7008473/ /pubmed/32055639 http://dx.doi.org/10.1093/ofid/ofaa025 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Crothers, Jessica W
Hsu, Liangge
Marty, Francisco M
Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient
title Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient
title_full Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient
title_fullStr Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient
title_full_unstemmed Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient
title_short Fulminant Acanthamoeba castellanii Encephalitis in an Ibrutinib-Treated Patient
title_sort fulminant acanthamoeba castellanii encephalitis in an ibrutinib-treated patient
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008473/
https://www.ncbi.nlm.nih.gov/pubmed/32055639
http://dx.doi.org/10.1093/ofid/ofaa025
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