Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish

The rapid and persistent increase of drug-resistant Mycobacterium tuberculosis (Mtb) infections poses increasing global problems in combatting tuberculosis (TB), prompting for the development of alternative strategies including host-directed therapy (HDT). Since Mtb is an intracellular pathogen with...

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Detalles Bibliográficos
Autores principales: Moreira, Jôsimar D., Koch, Bjørn E. V., van Veen, Suzanne, Walburg, Kimberley V., Vrieling, Frank, Mara Pinto Dabés Guimarães, Tânia, Meijer, Annemarie H., Spaink, Herman P., Ottenhoff, Tom H. M., Haks, Mariëlle C., Heemskerk, Matthias T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008710/
https://www.ncbi.nlm.nih.gov/pubmed/32117228
http://dx.doi.org/10.3389/fimmu.2020.00036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008710/
https://www.ncbi.nlm.nih.gov/pubmed/32117228
http://dx.doi.org/10.3389/fimmu.2020.00036

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