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Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63)

The food enzyme 4‐α‐d‐glucan glucohydrolase (EC 3.2.1.3) is produced with a genetically modified Trichoderma reesei DP‐Nzh63 by Danisco US Inc. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The...

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Autores principales: Silano, Vittorio, Barat Baviera, José Manuel, Bolognesi, Claudia, Cocconcelli, Pier Sandro, Crebelli, Riccardo, Gott, David Michael, Grob, Konrad, Lampi, Evgenia, Mortensen, Alicja, Rivière, Gilles, Steffensen, Inger‐Lise, Tlustos, Christina, Van Loveren, Henk, Vernis, Laurence, Zorn, Holger, Glandorf, Boet, Herman, Lieve, Aguilera, Jaime, Andryszkiewicz, Magdalena, Liu, Yi, Chesson, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008844/
https://www.ncbi.nlm.nih.gov/pubmed/32626124
http://dx.doi.org/10.2903/j.efsa.2019.5825
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author Silano, Vittorio
Barat Baviera, José Manuel
Bolognesi, Claudia
Cocconcelli, Pier Sandro
Crebelli, Riccardo
Gott, David Michael
Grob, Konrad
Lampi, Evgenia
Mortensen, Alicja
Rivière, Gilles
Steffensen, Inger‐Lise
Tlustos, Christina
Van Loveren, Henk
Vernis, Laurence
Zorn, Holger
Glandorf, Boet
Herman, Lieve
Aguilera, Jaime
Andryszkiewicz, Magdalena
Liu, Yi
Chesson, Andrew
author_facet Silano, Vittorio
Barat Baviera, José Manuel
Bolognesi, Claudia
Cocconcelli, Pier Sandro
Crebelli, Riccardo
Gott, David Michael
Grob, Konrad
Lampi, Evgenia
Mortensen, Alicja
Rivière, Gilles
Steffensen, Inger‐Lise
Tlustos, Christina
Van Loveren, Henk
Vernis, Laurence
Zorn, Holger
Glandorf, Boet
Herman, Lieve
Aguilera, Jaime
Andryszkiewicz, Magdalena
Liu, Yi
Chesson, Andrew
collection PubMed
description The food enzyme 4‐α‐d‐glucan glucohydrolase (EC 3.2.1.3) is produced with a genetically modified Trichoderma reesei DP‐Nzh63 by Danisco US Inc. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The glucan 1,4‐α‐glucosidase is intended to be used in distilled alcohol production. Since residual amounts of total organic solids are removed by distillation (> 99%), toxicological data were not considered necessary and dietary exposure was not calculated. Similarity of the amino acid sequence to those of known allergens was searched and no matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure can be excluded. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
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spelling pubmed-70088442020-07-02 Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63) Silano, Vittorio Barat Baviera, José Manuel Bolognesi, Claudia Cocconcelli, Pier Sandro Crebelli, Riccardo Gott, David Michael Grob, Konrad Lampi, Evgenia Mortensen, Alicja Rivière, Gilles Steffensen, Inger‐Lise Tlustos, Christina Van Loveren, Henk Vernis, Laurence Zorn, Holger Glandorf, Boet Herman, Lieve Aguilera, Jaime Andryszkiewicz, Magdalena Liu, Yi Chesson, Andrew EFSA J Scientific Opinion The food enzyme 4‐α‐d‐glucan glucohydrolase (EC 3.2.1.3) is produced with a genetically modified Trichoderma reesei DP‐Nzh63 by Danisco US Inc. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The glucan 1,4‐α‐glucosidase is intended to be used in distilled alcohol production. Since residual amounts of total organic solids are removed by distillation (> 99%), toxicological data were not considered necessary and dietary exposure was not calculated. Similarity of the amino acid sequence to those of known allergens was searched and no matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure can be excluded. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use. John Wiley and Sons Inc. 2019-10-17 /pmc/articles/PMC7008844/ /pubmed/32626124 http://dx.doi.org/10.2903/j.efsa.2019.5825 Text en © 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Silano, Vittorio
Barat Baviera, José Manuel
Bolognesi, Claudia
Cocconcelli, Pier Sandro
Crebelli, Riccardo
Gott, David Michael
Grob, Konrad
Lampi, Evgenia
Mortensen, Alicja
Rivière, Gilles
Steffensen, Inger‐Lise
Tlustos, Christina
Van Loveren, Henk
Vernis, Laurence
Zorn, Holger
Glandorf, Boet
Herman, Lieve
Aguilera, Jaime
Andryszkiewicz, Magdalena
Liu, Yi
Chesson, Andrew
Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63)
title Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63)
title_full Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63)
title_fullStr Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63)
title_full_unstemmed Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63)
title_short Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63)
title_sort safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from trichoderma reesei (strain dp‐nzh63)
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008844/
https://www.ncbi.nlm.nih.gov/pubmed/32626124
http://dx.doi.org/10.2903/j.efsa.2019.5825
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