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Safety of an essential oil from Origanum vulgare subsp. hirtum (Link) letsw. var. Vulkan when used as a sensory additive in feed for all animal species

An essential oil from Origanum vulgare subsp. hirtum var. Vulkan (DOS 00001) is intended to be used as a sensory additive in feed for all animal species. In a previous opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), the Panel concluded that the recommended...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Kouba, Maryline, Kos Durjava, Mojca, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Anguita, Montserrat, Galobart, Jaume, Holczknecht, Orsolya, Innocenti, Matteo Lorenzo, Tarrés‐Call, Jordi, Pettenati, Elisa, Pizzo, Fabiola, Manini, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009063/
https://www.ncbi.nlm.nih.gov/pubmed/32626396
http://dx.doi.org/10.2903/j.efsa.2019.5794
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kouba, Maryline
Kos Durjava, Mojca
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Anguita, Montserrat
Galobart, Jaume
Holczknecht, Orsolya
Innocenti, Matteo Lorenzo
Tarrés‐Call, Jordi
Pettenati, Elisa
Pizzo, Fabiola
Manini, Paola
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kouba, Maryline
Kos Durjava, Mojca
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Anguita, Montserrat
Galobart, Jaume
Holczknecht, Orsolya
Innocenti, Matteo Lorenzo
Tarrés‐Call, Jordi
Pettenati, Elisa
Pizzo, Fabiola
Manini, Paola
collection PubMed
description An essential oil from Origanum vulgare subsp. hirtum var. Vulkan (DOS 00001) is intended to be used as a sensory additive in feed for all animal species. In a previous opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), the Panel concluded that the recommended use level of 150 mg additive/kg feed was safe for chickens for fattening and weaned piglets and this conclusion was extended to all poultry and porcine species grown for meat production. The Panel also concluded that the dose of 500 mg additive/head and day (equivalent to ~25 mg/kg complete feed) was safe for dairy cows. Since the recommended use level differs between the dairy cow and the non‐ruminants tested, the lower use level of 25 mg additive/kg feed was applied to all target animals not included above. The Panel also concluded that the additive was safe for the consumers and the environment, but should be considered as an irritant to skin and eyes and a potential skin and respiratory sensitiser in susceptible individuals. In the present application, the applicant has provided a new tolerance study in dairy cows to support the safety of a higher use level of 150 mg/kg for all animal species. Data on residues in milk from dairy cows fed the additive at the maximum recommended use level where also provided to assess consumer exposure. The Panel concluded that the essential oil under assessment is safe for cows at the recommended use level of 150 mg additive/kg feed. Since safety has been demonstrated in three major species with a comparable margin of safety, this conclusion on safety is extrapolated to all animal species. No concerns for consumer safety were identified following the application of the additive at the proposed use level in animal nutrition.
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spelling pubmed-70090632020-07-02 Safety of an essential oil from Origanum vulgare subsp. hirtum (Link) letsw. var. Vulkan when used as a sensory additive in feed for all animal species Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Kouba, Maryline Kos Durjava, Mojca López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Anguita, Montserrat Galobart, Jaume Holczknecht, Orsolya Innocenti, Matteo Lorenzo Tarrés‐Call, Jordi Pettenati, Elisa Pizzo, Fabiola Manini, Paola EFSA J Scientific Opinion An essential oil from Origanum vulgare subsp. hirtum var. Vulkan (DOS 00001) is intended to be used as a sensory additive in feed for all animal species. In a previous opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), the Panel concluded that the recommended use level of 150 mg additive/kg feed was safe for chickens for fattening and weaned piglets and this conclusion was extended to all poultry and porcine species grown for meat production. The Panel also concluded that the dose of 500 mg additive/head and day (equivalent to ~25 mg/kg complete feed) was safe for dairy cows. Since the recommended use level differs between the dairy cow and the non‐ruminants tested, the lower use level of 25 mg additive/kg feed was applied to all target animals not included above. The Panel also concluded that the additive was safe for the consumers and the environment, but should be considered as an irritant to skin and eyes and a potential skin and respiratory sensitiser in susceptible individuals. In the present application, the applicant has provided a new tolerance study in dairy cows to support the safety of a higher use level of 150 mg/kg for all animal species. Data on residues in milk from dairy cows fed the additive at the maximum recommended use level where also provided to assess consumer exposure. The Panel concluded that the essential oil under assessment is safe for cows at the recommended use level of 150 mg additive/kg feed. Since safety has been demonstrated in three major species with a comparable margin of safety, this conclusion on safety is extrapolated to all animal species. No concerns for consumer safety were identified following the application of the additive at the proposed use level in animal nutrition. John Wiley and Sons Inc. 2019-07-25 /pmc/articles/PMC7009063/ /pubmed/32626396 http://dx.doi.org/10.2903/j.efsa.2019.5794 Text en © 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kouba, Maryline
Kos Durjava, Mojca
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Anguita, Montserrat
Galobart, Jaume
Holczknecht, Orsolya
Innocenti, Matteo Lorenzo
Tarrés‐Call, Jordi
Pettenati, Elisa
Pizzo, Fabiola
Manini, Paola
Safety of an essential oil from Origanum vulgare subsp. hirtum (Link) letsw. var. Vulkan when used as a sensory additive in feed for all animal species
title Safety of an essential oil from Origanum vulgare subsp. hirtum (Link) letsw. var. Vulkan when used as a sensory additive in feed for all animal species
title_full Safety of an essential oil from Origanum vulgare subsp. hirtum (Link) letsw. var. Vulkan when used as a sensory additive in feed for all animal species
title_fullStr Safety of an essential oil from Origanum vulgare subsp. hirtum (Link) letsw. var. Vulkan when used as a sensory additive in feed for all animal species
title_full_unstemmed Safety of an essential oil from Origanum vulgare subsp. hirtum (Link) letsw. var. Vulkan when used as a sensory additive in feed for all animal species
title_short Safety of an essential oil from Origanum vulgare subsp. hirtum (Link) letsw. var. Vulkan when used as a sensory additive in feed for all animal species
title_sort safety of an essential oil from origanum vulgare subsp. hirtum (link) letsw. var. vulkan when used as a sensory additive in feed for all animal species
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009063/
https://www.ncbi.nlm.nih.gov/pubmed/32626396
http://dx.doi.org/10.2903/j.efsa.2019.5794
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