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Establishment of cumulative assessment groups of pesticides for their effects on the thyroid

Cumulative assessment groups of pesticides have been established for two specific effects on the thyroid: firstly hypothyroidism, and secondly parafollicular cell (C‐cell) hypertrophy, hyperplasia and neoplasia. Sources of uncertainties resulting from the methodological approach and from the limitat...

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Detalles Bibliográficos
Autores principales: Crivellente, Federica, Hart, Andy, Hernandez‐Jerez, Antonio F., Hougaard Bennekou, Susanne, Pedersen, Ragnor, Terron, Andrea, Wolterink, Gerrit, Mohimont, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009157/
https://www.ncbi.nlm.nih.gov/pubmed/32626429
http://dx.doi.org/10.2903/j.efsa.2019.5801
Descripción
Sumario:Cumulative assessment groups of pesticides have been established for two specific effects on the thyroid: firstly hypothyroidism, and secondly parafollicular cell (C‐cell) hypertrophy, hyperplasia and neoplasia. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the thyroid, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.