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Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005

According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance clethodim. To assess the occurrence of clethodim residues in plants, processed commodities, rotational crops and live...

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Autores principales: Anastassiadou, Maria, Brancato, Alba, Carrasco Cabrera, Luis, Ferreira, Lucien, Greco, Luna, Jarrah, Samira, Kazocina, Aija, Leuschner, Renata, Magrans, Jose Oriol, Miron, Ileana, Pedersen, Ragnor, Raczyk, Marianna, Reich, Hermine, Ruocco, Silvia, Sacchi, Angela, Santos, Miguel, Stanek, Alois, Tarazona, Jose, Theobald, Anne, Verani, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009186/
https://www.ncbi.nlm.nih.gov/pubmed/32626327
http://dx.doi.org/10.2903/j.efsa.2019.5706
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author Anastassiadou, Maria
Brancato, Alba
Carrasco Cabrera, Luis
Ferreira, Lucien
Greco, Luna
Jarrah, Samira
Kazocina, Aija
Leuschner, Renata
Magrans, Jose Oriol
Miron, Ileana
Pedersen, Ragnor
Raczyk, Marianna
Reich, Hermine
Ruocco, Silvia
Sacchi, Angela
Santos, Miguel
Stanek, Alois
Tarazona, Jose
Theobald, Anne
Verani, Alessia
author_facet Anastassiadou, Maria
Brancato, Alba
Carrasco Cabrera, Luis
Ferreira, Lucien
Greco, Luna
Jarrah, Samira
Kazocina, Aija
Leuschner, Renata
Magrans, Jose Oriol
Miron, Ileana
Pedersen, Ragnor
Raczyk, Marianna
Reich, Hermine
Ruocco, Silvia
Sacchi, Angela
Santos, Miguel
Stanek, Alois
Tarazona, Jose
Theobald, Anne
Verani, Alessia
collection PubMed
description According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance clethodim. To assess the occurrence of clethodim residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission and European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, MRL could not be proposed because an overall consumer risk assessment could not be finalised. Risk managers should be made aware that the genotoxic potential of the clethodim metabolite 3‐chloroallyl alcohol, the aglycon of 3‐chlorolallyl alcohol glucoside (M14A/M15A) could not be concluded and no toxicological reference values could be derived for this metabolite. Until a conclusion on the toxicological properties of the metabolite is reached, a decision on the residue definition for risk assessment cannot be made which is a prerequisite to perform a reliable dietary risk assessment.
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spelling pubmed-70091862020-07-02 Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005 Anastassiadou, Maria Brancato, Alba Carrasco Cabrera, Luis Ferreira, Lucien Greco, Luna Jarrah, Samira Kazocina, Aija Leuschner, Renata Magrans, Jose Oriol Miron, Ileana Pedersen, Ragnor Raczyk, Marianna Reich, Hermine Ruocco, Silvia Sacchi, Angela Santos, Miguel Stanek, Alois Tarazona, Jose Theobald, Anne Verani, Alessia EFSA J Reasoned Opinion According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance clethodim. To assess the occurrence of clethodim residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission and European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, MRL could not be proposed because an overall consumer risk assessment could not be finalised. Risk managers should be made aware that the genotoxic potential of the clethodim metabolite 3‐chloroallyl alcohol, the aglycon of 3‐chlorolallyl alcohol glucoside (M14A/M15A) could not be concluded and no toxicological reference values could be derived for this metabolite. Until a conclusion on the toxicological properties of the metabolite is reached, a decision on the residue definition for risk assessment cannot be made which is a prerequisite to perform a reliable dietary risk assessment. John Wiley and Sons Inc. 2019-05-22 /pmc/articles/PMC7009186/ /pubmed/32626327 http://dx.doi.org/10.2903/j.efsa.2019.5706 Text en © 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Reasoned Opinion
Anastassiadou, Maria
Brancato, Alba
Carrasco Cabrera, Luis
Ferreira, Lucien
Greco, Luna
Jarrah, Samira
Kazocina, Aija
Leuschner, Renata
Magrans, Jose Oriol
Miron, Ileana
Pedersen, Ragnor
Raczyk, Marianna
Reich, Hermine
Ruocco, Silvia
Sacchi, Angela
Santos, Miguel
Stanek, Alois
Tarazona, Jose
Theobald, Anne
Verani, Alessia
Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005
title Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005
title_full Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005
title_fullStr Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005
title_full_unstemmed Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005
title_short Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005
title_sort review of the existing maximum residue levels for clethodim according to article 12 of regulation (ec) no 396/2005
topic Reasoned Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009186/
https://www.ncbi.nlm.nih.gov/pubmed/32626327
http://dx.doi.org/10.2903/j.efsa.2019.5706
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