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Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients

Colorectal cancer is the third most common cancer worldwide. New cancer treatment strategies such as monoclonal antibodies against growth factor and angiogenesis receptors have improved the overall survival (OS) and progression-free survival (PFS) in metastatic colorectal cancer (mCRC) patients. How...

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Autores principales: Kazemifard, Nesa, Sadeghi, Amir, Varaminian, Behnaz, Rezvani, Hamid, Ayadi, Ahmad, Talaie, Ramin, Moshiri, Arfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009314/
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author Kazemifard, Nesa
Sadeghi, Amir
Varaminian, Behnaz
Rezvani, Hamid
Ayadi, Ahmad
Talaie, Ramin
Moshiri, Arfa
author_facet Kazemifard, Nesa
Sadeghi, Amir
Varaminian, Behnaz
Rezvani, Hamid
Ayadi, Ahmad
Talaie, Ramin
Moshiri, Arfa
author_sort Kazemifard, Nesa
collection PubMed
description Colorectal cancer is the third most common cancer worldwide. New cancer treatment strategies such as monoclonal antibodies against growth factor and angiogenesis receptors have improved the overall survival (OS) and progression-free survival (PFS) in metastatic colorectal cancer (mCRC) patients. However, acquired resistance could happen after these therapies. Circulating tumor DNA (ctDNA) is the DNA fraction derived from tumor cells which could be applied as a non-invasive method for detecting tumor mutations before, during, and after therapies. Here, we reviewed most of the studies examining ctDNA as treatment monitoring in mCRC patients who receive different target therapies. Also, we compared ctDNA with other existing cancer-treatment monitoring methods.
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spelling pubmed-70093142020-02-25 Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients Kazemifard, Nesa Sadeghi, Amir Varaminian, Behnaz Rezvani, Hamid Ayadi, Ahmad Talaie, Ramin Moshiri, Arfa Gastroenterol Hepatol Bed Bench Review Article Colorectal cancer is the third most common cancer worldwide. New cancer treatment strategies such as monoclonal antibodies against growth factor and angiogenesis receptors have improved the overall survival (OS) and progression-free survival (PFS) in metastatic colorectal cancer (mCRC) patients. However, acquired resistance could happen after these therapies. Circulating tumor DNA (ctDNA) is the DNA fraction derived from tumor cells which could be applied as a non-invasive method for detecting tumor mutations before, during, and after therapies. Here, we reviewed most of the studies examining ctDNA as treatment monitoring in mCRC patients who receive different target therapies. Also, we compared ctDNA with other existing cancer-treatment monitoring methods. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC7009314/ Text en ©2019 RIGLD This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kazemifard, Nesa
Sadeghi, Amir
Varaminian, Behnaz
Rezvani, Hamid
Ayadi, Ahmad
Talaie, Ramin
Moshiri, Arfa
Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients
title Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients
title_full Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients
title_fullStr Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients
title_full_unstemmed Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients
title_short Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients
title_sort circulating tumor dna applications in monitoring the treatment of metastatic colorectal cancer patients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009314/
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