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Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients
Colorectal cancer is the third most common cancer worldwide. New cancer treatment strategies such as monoclonal antibodies against growth factor and angiogenesis receptors have improved the overall survival (OS) and progression-free survival (PFS) in metastatic colorectal cancer (mCRC) patients. How...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009314/ |
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author | Kazemifard, Nesa Sadeghi, Amir Varaminian, Behnaz Rezvani, Hamid Ayadi, Ahmad Talaie, Ramin Moshiri, Arfa |
author_facet | Kazemifard, Nesa Sadeghi, Amir Varaminian, Behnaz Rezvani, Hamid Ayadi, Ahmad Talaie, Ramin Moshiri, Arfa |
author_sort | Kazemifard, Nesa |
collection | PubMed |
description | Colorectal cancer is the third most common cancer worldwide. New cancer treatment strategies such as monoclonal antibodies against growth factor and angiogenesis receptors have improved the overall survival (OS) and progression-free survival (PFS) in metastatic colorectal cancer (mCRC) patients. However, acquired resistance could happen after these therapies. Circulating tumor DNA (ctDNA) is the DNA fraction derived from tumor cells which could be applied as a non-invasive method for detecting tumor mutations before, during, and after therapies. Here, we reviewed most of the studies examining ctDNA as treatment monitoring in mCRC patients who receive different target therapies. Also, we compared ctDNA with other existing cancer-treatment monitoring methods. |
format | Online Article Text |
id | pubmed-7009314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-70093142020-02-25 Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients Kazemifard, Nesa Sadeghi, Amir Varaminian, Behnaz Rezvani, Hamid Ayadi, Ahmad Talaie, Ramin Moshiri, Arfa Gastroenterol Hepatol Bed Bench Review Article Colorectal cancer is the third most common cancer worldwide. New cancer treatment strategies such as monoclonal antibodies against growth factor and angiogenesis receptors have improved the overall survival (OS) and progression-free survival (PFS) in metastatic colorectal cancer (mCRC) patients. However, acquired resistance could happen after these therapies. Circulating tumor DNA (ctDNA) is the DNA fraction derived from tumor cells which could be applied as a non-invasive method for detecting tumor mutations before, during, and after therapies. Here, we reviewed most of the studies examining ctDNA as treatment monitoring in mCRC patients who receive different target therapies. Also, we compared ctDNA with other existing cancer-treatment monitoring methods. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC7009314/ Text en ©2019 RIGLD This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kazemifard, Nesa Sadeghi, Amir Varaminian, Behnaz Rezvani, Hamid Ayadi, Ahmad Talaie, Ramin Moshiri, Arfa Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients |
title | Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients |
title_full | Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients |
title_fullStr | Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients |
title_full_unstemmed | Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients |
title_short | Circulating tumor DNA applications in monitoring the treatment of metastatic colorectal cancer patients |
title_sort | circulating tumor dna applications in monitoring the treatment of metastatic colorectal cancer patients |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009314/ |
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