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Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form

Low‐substituted hydroxypropyl cellulose (L‐HPC) is a low‐substituted poly(hydroxypropyl) ether of cellulose. L‐HPC is proposed for use as a food additive in food supplements in solid form (tablet), with a maximum use level of 20,000 mg/kg and a typical use level of 10,000 mg/kg. Exposure estimates t...

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Autores principales: Younes, Maged, Aggett, Peter, Aguilar, Fernando, Crebelli, Riccardo, Dusemund, Birgit, Filipič, Metka, Frutos, Maria Jose, Galtier, Pierre, Gundert‐Remy, Ursula, Kuhnle, Gunter Georg, Lambré, Claude, Leblanc, Jean‐Charles, Lillegaard, Inger Therese, Moldeus, Peter, Mortensen, Alicja, Oskarsson, Agneta, Stankovic, Ivan, Waalkens‐Berendsen, Ine, Woutersen, Rudolf Antonius, Wright, Matthew, Herman, Lieve, Tobback, Paul, Pizzo, Fabiola, Smeraldi, Camilla, Tard, Alexandra, Papaioannou, Adamantia, Gott, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009426/
https://www.ncbi.nlm.nih.gov/pubmed/32625653
http://dx.doi.org/10.2903/j.efsa.2018.5062
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author Younes, Maged
Aggett, Peter
Aguilar, Fernando
Crebelli, Riccardo
Dusemund, Birgit
Filipič, Metka
Frutos, Maria Jose
Galtier, Pierre
Gundert‐Remy, Ursula
Kuhnle, Gunter Georg
Lambré, Claude
Leblanc, Jean‐Charles
Lillegaard, Inger Therese
Moldeus, Peter
Mortensen, Alicja
Oskarsson, Agneta
Stankovic, Ivan
Waalkens‐Berendsen, Ine
Woutersen, Rudolf Antonius
Wright, Matthew
Herman, Lieve
Tobback, Paul
Pizzo, Fabiola
Smeraldi, Camilla
Tard, Alexandra
Papaioannou, Adamantia
Gott, David
author_facet Younes, Maged
Aggett, Peter
Aguilar, Fernando
Crebelli, Riccardo
Dusemund, Birgit
Filipič, Metka
Frutos, Maria Jose
Galtier, Pierre
Gundert‐Remy, Ursula
Kuhnle, Gunter Georg
Lambré, Claude
Leblanc, Jean‐Charles
Lillegaard, Inger Therese
Moldeus, Peter
Mortensen, Alicja
Oskarsson, Agneta
Stankovic, Ivan
Waalkens‐Berendsen, Ine
Woutersen, Rudolf Antonius
Wright, Matthew
Herman, Lieve
Tobback, Paul
Pizzo, Fabiola
Smeraldi, Camilla
Tard, Alexandra
Papaioannou, Adamantia
Gott, David
collection PubMed
description Low‐substituted hydroxypropyl cellulose (L‐HPC) is a low‐substituted poly(hydroxypropyl) ether of cellulose. L‐HPC is proposed for use as a food additive in food supplements in solid form (tablet), with a maximum use level of 20,000 mg/kg and a typical use level of 10,000 mg/kg. Exposure estimates to L‐HPC from its proposed use were calculated for both typical and maximum use levels. Due to the close chemical relationship between L‐HPC and other celluloses recently re‐evaluated by EFSA, the Panel decided to read‐across the biological data already evaluated in the context of the re‐evaluation programme. The Panel concluded that there was no safety concern from the proposed use and use levels of L‐HPC.
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spelling pubmed-70094262020-07-02 Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form Younes, Maged Aggett, Peter Aguilar, Fernando Crebelli, Riccardo Dusemund, Birgit Filipič, Metka Frutos, Maria Jose Galtier, Pierre Gundert‐Remy, Ursula Kuhnle, Gunter Georg Lambré, Claude Leblanc, Jean‐Charles Lillegaard, Inger Therese Moldeus, Peter Mortensen, Alicja Oskarsson, Agneta Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Herman, Lieve Tobback, Paul Pizzo, Fabiola Smeraldi, Camilla Tard, Alexandra Papaioannou, Adamantia Gott, David EFSA J Scientific Opinion Low‐substituted hydroxypropyl cellulose (L‐HPC) is a low‐substituted poly(hydroxypropyl) ether of cellulose. L‐HPC is proposed for use as a food additive in food supplements in solid form (tablet), with a maximum use level of 20,000 mg/kg and a typical use level of 10,000 mg/kg. Exposure estimates to L‐HPC from its proposed use were calculated for both typical and maximum use levels. Due to the close chemical relationship between L‐HPC and other celluloses recently re‐evaluated by EFSA, the Panel decided to read‐across the biological data already evaluated in the context of the re‐evaluation programme. The Panel concluded that there was no safety concern from the proposed use and use levels of L‐HPC. John Wiley and Sons Inc. 2018-01-20 /pmc/articles/PMC7009426/ /pubmed/32625653 http://dx.doi.org/10.2903/j.efsa.2018.5062 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Younes, Maged
Aggett, Peter
Aguilar, Fernando
Crebelli, Riccardo
Dusemund, Birgit
Filipič, Metka
Frutos, Maria Jose
Galtier, Pierre
Gundert‐Remy, Ursula
Kuhnle, Gunter Georg
Lambré, Claude
Leblanc, Jean‐Charles
Lillegaard, Inger Therese
Moldeus, Peter
Mortensen, Alicja
Oskarsson, Agneta
Stankovic, Ivan
Waalkens‐Berendsen, Ine
Woutersen, Rudolf Antonius
Wright, Matthew
Herman, Lieve
Tobback, Paul
Pizzo, Fabiola
Smeraldi, Camilla
Tard, Alexandra
Papaioannou, Adamantia
Gott, David
Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form
title Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form
title_full Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form
title_fullStr Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form
title_full_unstemmed Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form
title_short Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form
title_sort safety of low‐substituted hydroxypropyl cellulose (l‐hpc) to be used as a food additive in food supplements in tablet form
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009426/
https://www.ncbi.nlm.nih.gov/pubmed/32625653
http://dx.doi.org/10.2903/j.efsa.2018.5062
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