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Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form
Low‐substituted hydroxypropyl cellulose (L‐HPC) is a low‐substituted poly(hydroxypropyl) ether of cellulose. L‐HPC is proposed for use as a food additive in food supplements in solid form (tablet), with a maximum use level of 20,000 mg/kg and a typical use level of 10,000 mg/kg. Exposure estimates t...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009426/ https://www.ncbi.nlm.nih.gov/pubmed/32625653 http://dx.doi.org/10.2903/j.efsa.2018.5062 |
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author | Younes, Maged Aggett, Peter Aguilar, Fernando Crebelli, Riccardo Dusemund, Birgit Filipič, Metka Frutos, Maria Jose Galtier, Pierre Gundert‐Remy, Ursula Kuhnle, Gunter Georg Lambré, Claude Leblanc, Jean‐Charles Lillegaard, Inger Therese Moldeus, Peter Mortensen, Alicja Oskarsson, Agneta Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Herman, Lieve Tobback, Paul Pizzo, Fabiola Smeraldi, Camilla Tard, Alexandra Papaioannou, Adamantia Gott, David |
author_facet | Younes, Maged Aggett, Peter Aguilar, Fernando Crebelli, Riccardo Dusemund, Birgit Filipič, Metka Frutos, Maria Jose Galtier, Pierre Gundert‐Remy, Ursula Kuhnle, Gunter Georg Lambré, Claude Leblanc, Jean‐Charles Lillegaard, Inger Therese Moldeus, Peter Mortensen, Alicja Oskarsson, Agneta Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Herman, Lieve Tobback, Paul Pizzo, Fabiola Smeraldi, Camilla Tard, Alexandra Papaioannou, Adamantia Gott, David |
collection | PubMed |
description | Low‐substituted hydroxypropyl cellulose (L‐HPC) is a low‐substituted poly(hydroxypropyl) ether of cellulose. L‐HPC is proposed for use as a food additive in food supplements in solid form (tablet), with a maximum use level of 20,000 mg/kg and a typical use level of 10,000 mg/kg. Exposure estimates to L‐HPC from its proposed use were calculated for both typical and maximum use levels. Due to the close chemical relationship between L‐HPC and other celluloses recently re‐evaluated by EFSA, the Panel decided to read‐across the biological data already evaluated in the context of the re‐evaluation programme. The Panel concluded that there was no safety concern from the proposed use and use levels of L‐HPC. |
format | Online Article Text |
id | pubmed-7009426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70094262020-07-02 Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form Younes, Maged Aggett, Peter Aguilar, Fernando Crebelli, Riccardo Dusemund, Birgit Filipič, Metka Frutos, Maria Jose Galtier, Pierre Gundert‐Remy, Ursula Kuhnle, Gunter Georg Lambré, Claude Leblanc, Jean‐Charles Lillegaard, Inger Therese Moldeus, Peter Mortensen, Alicja Oskarsson, Agneta Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Herman, Lieve Tobback, Paul Pizzo, Fabiola Smeraldi, Camilla Tard, Alexandra Papaioannou, Adamantia Gott, David EFSA J Scientific Opinion Low‐substituted hydroxypropyl cellulose (L‐HPC) is a low‐substituted poly(hydroxypropyl) ether of cellulose. L‐HPC is proposed for use as a food additive in food supplements in solid form (tablet), with a maximum use level of 20,000 mg/kg and a typical use level of 10,000 mg/kg. Exposure estimates to L‐HPC from its proposed use were calculated for both typical and maximum use levels. Due to the close chemical relationship between L‐HPC and other celluloses recently re‐evaluated by EFSA, the Panel decided to read‐across the biological data already evaluated in the context of the re‐evaluation programme. The Panel concluded that there was no safety concern from the proposed use and use levels of L‐HPC. John Wiley and Sons Inc. 2018-01-20 /pmc/articles/PMC7009426/ /pubmed/32625653 http://dx.doi.org/10.2903/j.efsa.2018.5062 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Younes, Maged Aggett, Peter Aguilar, Fernando Crebelli, Riccardo Dusemund, Birgit Filipič, Metka Frutos, Maria Jose Galtier, Pierre Gundert‐Remy, Ursula Kuhnle, Gunter Georg Lambré, Claude Leblanc, Jean‐Charles Lillegaard, Inger Therese Moldeus, Peter Mortensen, Alicja Oskarsson, Agneta Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Herman, Lieve Tobback, Paul Pizzo, Fabiola Smeraldi, Camilla Tard, Alexandra Papaioannou, Adamantia Gott, David Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form |
title | Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form |
title_full | Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form |
title_fullStr | Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form |
title_full_unstemmed | Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form |
title_short | Safety of low‐substituted hydroxypropyl cellulose (L‐HPC) to be used as a food additive in food supplements in tablet form |
title_sort | safety of low‐substituted hydroxypropyl cellulose (l‐hpc) to be used as a food additive in food supplements in tablet form |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009426/ https://www.ncbi.nlm.nih.gov/pubmed/32625653 http://dx.doi.org/10.2903/j.efsa.2018.5062 |
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