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Safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying. Coxiril(®), containing 0.5% diclazuril, is...

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Autores principales: Rychen, Guido, Aquilina, Gabriele, Azimonti, Giovanna, Bampidis, Vasileios, Bastos, Maria de Lourdes, Bories, Georges, Chesson, Andrew, Cocconcelli, Pier Sandro, Flachowsky, Gerhard, Kolar, Boris, Kouba, Maryline, López Alonso, Marta, López Puente, Secundino, Mantovani, Alberto, Mayo, Baltasar, Ramos, Fernando, Saarela, Maria, Villa, Roberto Edoardo, Wallace, Robert John, Wester, Pieter, Brantom, Paul, Halle, Ingrid, van Beelen, Patrick, Holczknecht, Orsolya, Vettori, Maria Vittoria, Gropp, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009511/
https://www.ncbi.nlm.nih.gov/pubmed/32625831
http://dx.doi.org/10.2903/j.efsa.2018.5195
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author Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Halle, Ingrid
van Beelen, Patrick
Holczknecht, Orsolya
Vettori, Maria Vittoria
Gropp, Jürgen
author_facet Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Halle, Ingrid
van Beelen, Patrick
Holczknecht, Orsolya
Vettori, Maria Vittoria
Gropp, Jürgen
collection PubMed
description Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying. Coxiril(®), containing 0.5% diclazuril, is intended for the prevention of coccidiosis in chickens reared for laying at a dose range of 0.8–1.2 mg diclazuril/kg of complete feed up to a maximum age of 12 weeks. Derived from data already assessed for chickens and turkeys for fattening, diclazuril from Coxiril(®) is safe for chickens reared for laying up to 1.2 mg/kg complete feed when applied until 12 weeks of age. The FEEDAP Panel extended its previous assessment of consumer safety for the use of diclazuril from Coxiril(®) in chickens for fattening to chickens reared for laying. No measurable diclazuril residues were found in the first eggs laid from chickens reared for laying fed diclazuril from Coxiril(®) at 1.2 mg/kg complete feed until 12 weeks of age. Coxiril(®) was considered as a non‐irritant to eyes and skin. It is not a potential skin sensitiser. User inhalation exposure to Coxiril(®), as a result of normal handling, is unlikely to cause respiratory or systemic toxicity. The use of diclazuril from Coxiril(®) in chickens reared for laying at the highest proposed feed concentration would not pose a risk to the environment for neutral/alkaline soils (pH ≥ 7). A final conclusion on the risk resulting from the use of diclazuril in acid soil from Coxiril(®) cannot be done due to the high uncertainties related to potential accumulation of diclazuril over time. Derived from data already assessed for chickens for fattening, diclazuril from Coxiril(®) has the potential to control coccidiosis in chickens reared for laying at a minimum concentration of 0.8 mg/kg complete feed.
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spelling pubmed-70095112020-07-02 Safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brantom, Paul Halle, Ingrid van Beelen, Patrick Holczknecht, Orsolya Vettori, Maria Vittoria Gropp, Jürgen EFSA J Scientific Opinion Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying. Coxiril(®), containing 0.5% diclazuril, is intended for the prevention of coccidiosis in chickens reared for laying at a dose range of 0.8–1.2 mg diclazuril/kg of complete feed up to a maximum age of 12 weeks. Derived from data already assessed for chickens and turkeys for fattening, diclazuril from Coxiril(®) is safe for chickens reared for laying up to 1.2 mg/kg complete feed when applied until 12 weeks of age. The FEEDAP Panel extended its previous assessment of consumer safety for the use of diclazuril from Coxiril(®) in chickens for fattening to chickens reared for laying. No measurable diclazuril residues were found in the first eggs laid from chickens reared for laying fed diclazuril from Coxiril(®) at 1.2 mg/kg complete feed until 12 weeks of age. Coxiril(®) was considered as a non‐irritant to eyes and skin. It is not a potential skin sensitiser. User inhalation exposure to Coxiril(®), as a result of normal handling, is unlikely to cause respiratory or systemic toxicity. The use of diclazuril from Coxiril(®) in chickens reared for laying at the highest proposed feed concentration would not pose a risk to the environment for neutral/alkaline soils (pH ≥ 7). A final conclusion on the risk resulting from the use of diclazuril in acid soil from Coxiril(®) cannot be done due to the high uncertainties related to potential accumulation of diclazuril over time. Derived from data already assessed for chickens for fattening, diclazuril from Coxiril(®) has the potential to control coccidiosis in chickens reared for laying at a minimum concentration of 0.8 mg/kg complete feed. John Wiley and Sons Inc. 2018-03-29 /pmc/articles/PMC7009511/ /pubmed/32625831 http://dx.doi.org/10.2903/j.efsa.2018.5195 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Halle, Ingrid
van Beelen, Patrick
Holczknecht, Orsolya
Vettori, Maria Vittoria
Gropp, Jürgen
Safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying
title Safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying
title_full Safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying
title_fullStr Safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying
title_full_unstemmed Safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying
title_short Safety and efficacy of Coxiril(®) (diclazuril) for chickens reared for laying
title_sort safety and efficacy of coxiril(®) (diclazuril) for chickens reared for laying
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009511/
https://www.ncbi.nlm.nih.gov/pubmed/32625831
http://dx.doi.org/10.2903/j.efsa.2018.5195
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