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Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9
The GMO Panel has previously assessed genetically modified (GM) soybean BPS‐CV127‐9. This soybean was found to be as safe and nutritious as its conventional counterpart and commercial soybean varieties with respect to potential effects on human and animal health and the environment in the context of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009553/ https://www.ncbi.nlm.nih.gov/pubmed/32626051 http://dx.doi.org/10.2903/j.efsa.2018.5425 |
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author | Papadopoulou, Nikoletta Ramon, Matthew |
author_facet | Papadopoulou, Nikoletta Ramon, Matthew |
collection | PubMed |
description | The GMO Panel has previously assessed genetically modified (GM) soybean BPS‐CV127‐9. This soybean was found to be as safe and nutritious as its conventional counterpart and commercial soybean varieties with respect to potential effects on human and animal health and the environment in the context of its intended uses. On 16 February 2018, European Commission requested EFSA to analyse new nucleic acid sequencing data and updated bioinformatics data for GM soybean BPS‐CV127‐9 and to indicate whether the previous conclusions of the GMO Panel on safety of GM soybean BPS‐CV127‐9 remain valid. The new sequencing data indicated a two nucleotide difference in the unannotated Arabidopsis genomic DNA sequence downstream of the 3′ untranslated region of the ahasl (also referred to as csr1‐2) gene as compared to the sequencing data originally provided. One of these nucleotide differences reported in the new nucleic acid sequencing data from GM soybean event BPS‐CV127‐9 was shown to be already present in the original plant material used for the risk assessment. However, for the other nucleotide difference reported, no evidence could be provided to differentiate between a sequencing error and point‐mutation. With the exception of bioinformatics analyses, the studies performed for the risk assessment of the single event soybean BPS‐CV127‐9 remain valid. The new sequencing data and the bioinformatics analyses performed on the new sequence did not give rise to safety issues. Therefore, EFSA concludes that the original risk assessment of soybean BPS‐CV127‐9 remains valid. |
format | Online Article Text |
id | pubmed-7009553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70095532020-07-02 Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9 Papadopoulou, Nikoletta Ramon, Matthew EFSA J EFSA Statement The GMO Panel has previously assessed genetically modified (GM) soybean BPS‐CV127‐9. This soybean was found to be as safe and nutritious as its conventional counterpart and commercial soybean varieties with respect to potential effects on human and animal health and the environment in the context of its intended uses. On 16 February 2018, European Commission requested EFSA to analyse new nucleic acid sequencing data and updated bioinformatics data for GM soybean BPS‐CV127‐9 and to indicate whether the previous conclusions of the GMO Panel on safety of GM soybean BPS‐CV127‐9 remain valid. The new sequencing data indicated a two nucleotide difference in the unannotated Arabidopsis genomic DNA sequence downstream of the 3′ untranslated region of the ahasl (also referred to as csr1‐2) gene as compared to the sequencing data originally provided. One of these nucleotide differences reported in the new nucleic acid sequencing data from GM soybean event BPS‐CV127‐9 was shown to be already present in the original plant material used for the risk assessment. However, for the other nucleotide difference reported, no evidence could be provided to differentiate between a sequencing error and point‐mutation. With the exception of bioinformatics analyses, the studies performed for the risk assessment of the single event soybean BPS‐CV127‐9 remain valid. The new sequencing data and the bioinformatics analyses performed on the new sequence did not give rise to safety issues. Therefore, EFSA concludes that the original risk assessment of soybean BPS‐CV127‐9 remains valid. John Wiley and Sons Inc. 2018-09-21 /pmc/articles/PMC7009553/ /pubmed/32626051 http://dx.doi.org/10.2903/j.efsa.2018.5425 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | EFSA Statement Papadopoulou, Nikoletta Ramon, Matthew Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9 |
title | Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9 |
title_full | Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9 |
title_fullStr | Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9 |
title_full_unstemmed | Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9 |
title_short | Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9 |
title_sort | risk assessment of new sequencing information for genetically modified soybean bps‐cv127‐9 |
topic | EFSA Statement |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009553/ https://www.ncbi.nlm.nih.gov/pubmed/32626051 http://dx.doi.org/10.2903/j.efsa.2018.5425 |
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