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Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9

The GMO Panel has previously assessed genetically modified (GM) soybean BPS‐CV127‐9. This soybean was found to be as safe and nutritious as its conventional counterpart and commercial soybean varieties with respect to potential effects on human and animal health and the environment in the context of...

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Autores principales: Papadopoulou, Nikoletta, Ramon, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009553/
https://www.ncbi.nlm.nih.gov/pubmed/32626051
http://dx.doi.org/10.2903/j.efsa.2018.5425
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author Papadopoulou, Nikoletta
Ramon, Matthew
author_facet Papadopoulou, Nikoletta
Ramon, Matthew
collection PubMed
description The GMO Panel has previously assessed genetically modified (GM) soybean BPS‐CV127‐9. This soybean was found to be as safe and nutritious as its conventional counterpart and commercial soybean varieties with respect to potential effects on human and animal health and the environment in the context of its intended uses. On 16 February 2018, European Commission requested EFSA to analyse new nucleic acid sequencing data and updated bioinformatics data for GM soybean BPS‐CV127‐9 and to indicate whether the previous conclusions of the GMO Panel on safety of GM soybean BPS‐CV127‐9 remain valid. The new sequencing data indicated a two nucleotide difference in the unannotated Arabidopsis genomic DNA sequence downstream of the 3′ untranslated region of the ahasl (also referred to as csr1‐2) gene as compared to the sequencing data originally provided. One of these nucleotide differences reported in the new nucleic acid sequencing data from GM soybean event BPS‐CV127‐9 was shown to be already present in the original plant material used for the risk assessment. However, for the other nucleotide difference reported, no evidence could be provided to differentiate between a sequencing error and point‐mutation. With the exception of bioinformatics analyses, the studies performed for the risk assessment of the single event soybean BPS‐CV127‐9 remain valid. The new sequencing data and the bioinformatics analyses performed on the new sequence did not give rise to safety issues. Therefore, EFSA concludes that the original risk assessment of soybean BPS‐CV127‐9 remains valid.
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spelling pubmed-70095532020-07-02 Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9 Papadopoulou, Nikoletta Ramon, Matthew EFSA J EFSA Statement The GMO Panel has previously assessed genetically modified (GM) soybean BPS‐CV127‐9. This soybean was found to be as safe and nutritious as its conventional counterpart and commercial soybean varieties with respect to potential effects on human and animal health and the environment in the context of its intended uses. On 16 February 2018, European Commission requested EFSA to analyse new nucleic acid sequencing data and updated bioinformatics data for GM soybean BPS‐CV127‐9 and to indicate whether the previous conclusions of the GMO Panel on safety of GM soybean BPS‐CV127‐9 remain valid. The new sequencing data indicated a two nucleotide difference in the unannotated Arabidopsis genomic DNA sequence downstream of the 3′ untranslated region of the ahasl (also referred to as csr1‐2) gene as compared to the sequencing data originally provided. One of these nucleotide differences reported in the new nucleic acid sequencing data from GM soybean event BPS‐CV127‐9 was shown to be already present in the original plant material used for the risk assessment. However, for the other nucleotide difference reported, no evidence could be provided to differentiate between a sequencing error and point‐mutation. With the exception of bioinformatics analyses, the studies performed for the risk assessment of the single event soybean BPS‐CV127‐9 remain valid. The new sequencing data and the bioinformatics analyses performed on the new sequence did not give rise to safety issues. Therefore, EFSA concludes that the original risk assessment of soybean BPS‐CV127‐9 remains valid. John Wiley and Sons Inc. 2018-09-21 /pmc/articles/PMC7009553/ /pubmed/32626051 http://dx.doi.org/10.2903/j.efsa.2018.5425 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle EFSA Statement
Papadopoulou, Nikoletta
Ramon, Matthew
Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9
title Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9
title_full Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9
title_fullStr Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9
title_full_unstemmed Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9
title_short Risk assessment of new sequencing information for genetically modified soybean BPS‐CV127‐9
title_sort risk assessment of new sequencing information for genetically modified soybean bps‐cv127‐9
topic EFSA Statement
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009553/
https://www.ncbi.nlm.nih.gov/pubmed/32626051
http://dx.doi.org/10.2903/j.efsa.2018.5425
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