Cargando…
Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species
Butylated hydroxyanisole (BHA) is a waxy solid consisting for > 98.5% of the active substance, a mixture of 3‐tert‐butyl‐4‐hydroxyanisole and 2‐tert‐butyl‐4‐hydroxyanisole. It is intended to be used as an antioxidant in feedingstuffs for all animal species and categories. The Panel on Additives a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009650/ https://www.ncbi.nlm.nih.gov/pubmed/32625845 http://dx.doi.org/10.2903/j.efsa.2018.5215 |
_version_ | 1783495714567880704 |
---|---|
author | Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen |
author_facet | Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen |
collection | PubMed |
description | Butylated hydroxyanisole (BHA) is a waxy solid consisting for > 98.5% of the active substance, a mixture of 3‐tert‐butyl‐4‐hydroxyanisole and 2‐tert‐butyl‐4‐hydroxyanisole. It is intended to be used as an antioxidant in feedingstuffs for all animal species and categories. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) considered BHA up to 150 mg/kg complete feed as safe for all animal species except for cats, for which a safe dose could not be established from the tolerance data. BHA is rapidly absorbed from the gastrointestinal tract; it is metabolised rapidly and excreted as such and as metabolites in the urine and faeces. The proportions of the different metabolites vary depending on species and dose. No accumulation of BHA or metabolites was observed in tissues. The Panel concluded that no concern for consumer safety would arise from the use of BHA as a feed additive at the maximum concentration of 150 mg/kg feed. The additive should be considered a skin, eye irritant and a potential skin sensitiser. Exposure of the user via inhalation was considered unlikely; therefore, a risk is not expected. The use of BHA at the maximum concentration proposed is unlikely to pose a risk to the environment. BHA is authorised as an antioxidant for food use at comparable use levels, therefore, no studies were required to demonstrate the efficacy of BHA as an antioxidant in feedingstuffs for all animal species. |
format | Online Article Text |
id | pubmed-7009650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70096502020-07-02 Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen EFSA J Scientific Opinion Butylated hydroxyanisole (BHA) is a waxy solid consisting for > 98.5% of the active substance, a mixture of 3‐tert‐butyl‐4‐hydroxyanisole and 2‐tert‐butyl‐4‐hydroxyanisole. It is intended to be used as an antioxidant in feedingstuffs for all animal species and categories. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) considered BHA up to 150 mg/kg complete feed as safe for all animal species except for cats, for which a safe dose could not be established from the tolerance data. BHA is rapidly absorbed from the gastrointestinal tract; it is metabolised rapidly and excreted as such and as metabolites in the urine and faeces. The proportions of the different metabolites vary depending on species and dose. No accumulation of BHA or metabolites was observed in tissues. The Panel concluded that no concern for consumer safety would arise from the use of BHA as a feed additive at the maximum concentration of 150 mg/kg feed. The additive should be considered a skin, eye irritant and a potential skin sensitiser. Exposure of the user via inhalation was considered unlikely; therefore, a risk is not expected. The use of BHA at the maximum concentration proposed is unlikely to pose a risk to the environment. BHA is authorised as an antioxidant for food use at comparable use levels, therefore, no studies were required to demonstrate the efficacy of BHA as an antioxidant in feedingstuffs for all animal species. John Wiley and Sons Inc. 2018-03-28 /pmc/articles/PMC7009650/ /pubmed/32625845 http://dx.doi.org/10.2903/j.efsa.2018.5215 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species |
title | Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species |
title_full | Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species |
title_fullStr | Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species |
title_full_unstemmed | Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species |
title_short | Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species |
title_sort | safety and efficacy of butylated hydroxyanisole (bha) as a feed additive for all animal species |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009650/ https://www.ncbi.nlm.nih.gov/pubmed/32625845 http://dx.doi.org/10.2903/j.efsa.2018.5215 |
work_keys_str_mv | AT safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT rychenguido safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT aquilinagabriele safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT azimontigiovanna safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT bampidisvasileios safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT bastosmariadelourdes safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT boriesgeorges safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT chessonandrew safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT cocconcellipiersandro safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT flachowskygerhard safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT kolarboris safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT koubamaryline safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT lopezalonsomarta safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT puentesecundinolopez safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT mantovanialberto safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT mayobaltasar safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT ramosfernando safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT saarelamaria safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT villarobertoedoardo safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT wallacerobertjohn safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT westerpieter safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT lundebyeannekatrine safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT nebbiacarlo safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT renshawderek safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT innocentimatteolorenzo safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies AT groppjurgen safetyandefficacyofbutylatedhydroxyanisolebhaasafeedadditiveforallanimalspecies |