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Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species

Butylated hydroxyanisole (BHA) is a waxy solid consisting for > 98.5% of the active substance, a mixture of 3‐tert‐butyl‐4‐hydroxyanisole and 2‐tert‐butyl‐4‐hydroxyanisole. It is intended to be used as an antioxidant in feedingstuffs for all animal species and categories. The Panel on Additives a...

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Autores principales: Rychen, Guido, Aquilina, Gabriele, Azimonti, Giovanna, Bampidis, Vasileios, Bastos, Maria de Lourdes, Bories, Georges, Chesson, Andrew, Cocconcelli, Pier Sandro, Flachowsky, Gerhard, Kolar, Boris, Kouba, Maryline, López‐Alonso, Marta, Puente, Secundino López, Mantovani, Alberto, Mayo, Baltasar, Ramos, Fernando, Saarela, Maria, Villa, Roberto Edoardo, Wallace, Robert John, Wester, Pieter, Lundebye, Anne‐Katrine, Nebbia, Carlo, Renshaw, Derek, Innocenti, Matteo Lorenzo, Gropp, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009650/
https://www.ncbi.nlm.nih.gov/pubmed/32625845
http://dx.doi.org/10.2903/j.efsa.2018.5215
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author Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
Puente, Secundino López
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Lundebye, Anne‐Katrine
Nebbia, Carlo
Renshaw, Derek
Innocenti, Matteo Lorenzo
Gropp, Jürgen
author_facet Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
Puente, Secundino López
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Lundebye, Anne‐Katrine
Nebbia, Carlo
Renshaw, Derek
Innocenti, Matteo Lorenzo
Gropp, Jürgen
collection PubMed
description Butylated hydroxyanisole (BHA) is a waxy solid consisting for > 98.5% of the active substance, a mixture of 3‐tert‐butyl‐4‐hydroxyanisole and 2‐tert‐butyl‐4‐hydroxyanisole. It is intended to be used as an antioxidant in feedingstuffs for all animal species and categories. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) considered BHA up to 150 mg/kg complete feed as safe for all animal species except for cats, for which a safe dose could not be established from the tolerance data. BHA is rapidly absorbed from the gastrointestinal tract; it is metabolised rapidly and excreted as such and as metabolites in the urine and faeces. The proportions of the different metabolites vary depending on species and dose. No accumulation of BHA or metabolites was observed in tissues. The Panel concluded that no concern for consumer safety would arise from the use of BHA as a feed additive at the maximum concentration of 150 mg/kg feed. The additive should be considered a skin, eye irritant and a potential skin sensitiser. Exposure of the user via inhalation was considered unlikely; therefore, a risk is not expected. The use of BHA at the maximum concentration proposed is unlikely to pose a risk to the environment. BHA is authorised as an antioxidant for food use at comparable use levels, therefore, no studies were required to demonstrate the efficacy of BHA as an antioxidant in feedingstuffs for all animal species.
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spelling pubmed-70096502020-07-02 Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen EFSA J Scientific Opinion Butylated hydroxyanisole (BHA) is a waxy solid consisting for > 98.5% of the active substance, a mixture of 3‐tert‐butyl‐4‐hydroxyanisole and 2‐tert‐butyl‐4‐hydroxyanisole. It is intended to be used as an antioxidant in feedingstuffs for all animal species and categories. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) considered BHA up to 150 mg/kg complete feed as safe for all animal species except for cats, for which a safe dose could not be established from the tolerance data. BHA is rapidly absorbed from the gastrointestinal tract; it is metabolised rapidly and excreted as such and as metabolites in the urine and faeces. The proportions of the different metabolites vary depending on species and dose. No accumulation of BHA or metabolites was observed in tissues. The Panel concluded that no concern for consumer safety would arise from the use of BHA as a feed additive at the maximum concentration of 150 mg/kg feed. The additive should be considered a skin, eye irritant and a potential skin sensitiser. Exposure of the user via inhalation was considered unlikely; therefore, a risk is not expected. The use of BHA at the maximum concentration proposed is unlikely to pose a risk to the environment. BHA is authorised as an antioxidant for food use at comparable use levels, therefore, no studies were required to demonstrate the efficacy of BHA as an antioxidant in feedingstuffs for all animal species. John Wiley and Sons Inc. 2018-03-28 /pmc/articles/PMC7009650/ /pubmed/32625845 http://dx.doi.org/10.2903/j.efsa.2018.5215 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
Puente, Secundino López
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Lundebye, Anne‐Katrine
Nebbia, Carlo
Renshaw, Derek
Innocenti, Matteo Lorenzo
Gropp, Jürgen
Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species
title Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species
title_full Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species
title_fullStr Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species
title_full_unstemmed Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species
title_short Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species
title_sort safety and efficacy of butylated hydroxyanisole (bha) as a feed additive for all animal species
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009650/
https://www.ncbi.nlm.nih.gov/pubmed/32625845
http://dx.doi.org/10.2903/j.efsa.2018.5215
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