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Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of flavouring substances from subgroup 1.1.4 of FGE.19 in the Flavouring Group Evaluation 203 Revision 2 (FGE.203Rev2). In FGE. 203 Re...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009657/ https://www.ncbi.nlm.nih.gov/pubmed/32625963 http://dx.doi.org/10.2903/j.efsa.2018.5322 |
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author | Silano, Vittorio Bolognesi, Claudia Castle, Laurence Chipman, Kevin Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Husøy, Trine Kärenlampi, Sirpa Mennes, Wim Milana, Maria Rosaria Pfaff, Karla Riviere, Gilles Srinivasan, Jannavi Tavares Poças, Maria de Fátima Tlustos, Christina Wölfle, Detlef Zorn, Holger Binderup, Mona‐Lise Marcon, Francesca Marzin, Daniel Mosesso, Pasquale Anastassiadou, Maria Carfì, Maria Gürtler, Rainer |
author_facet | Silano, Vittorio Bolognesi, Claudia Castle, Laurence Chipman, Kevin Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Husøy, Trine Kärenlampi, Sirpa Mennes, Wim Milana, Maria Rosaria Pfaff, Karla Riviere, Gilles Srinivasan, Jannavi Tavares Poças, Maria de Fátima Tlustos, Christina Wölfle, Detlef Zorn, Holger Binderup, Mona‐Lise Marcon, Francesca Marzin, Daniel Mosesso, Pasquale Anastassiadou, Maria Carfì, Maria Gürtler, Rainer |
collection | PubMed |
description | The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of flavouring substances from subgroup 1.1.4 of FGE.19 in the Flavouring Group Evaluation 203 Revision 2 (FGE.203Rev2). In FGE. 203 Revision 1, the Panel concluded that the genotoxic potential could not be ruled out for the flavouring substances in this FGE. The Flavour Industry provided additional genotoxicity studies for the representative substances of FGE.19 subgroup 1.1.4, namely deca‐2(trans),4(trans)‐dienal [FL‐no: 05.140] and hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057]. In addition, new studies on hepta‐2,4‐dienal [FL‐no: 05.084], 2,4‐octadienal [FL‐no: 05.186] and tr‐2,tr‐4‐nonadienal [FL‐no: 05.194] were provided that are evaluated in the present revision of FGE.203, i.e. FGE.203Rev2. Hepta‐2,4‐dienal [FL‐no: 05.084], 2,4‐octadienal [FL‐no: 05.186] and tr‐2,tr‐4‐nonadienal [FL‐no: 05.194] did not induce gene mutations in bacteria. Hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057] did not induce gene mutations in vitro in mammalian cells. Hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057] was also tested in an in vivo gene mutation assay giving negative results. Both hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057] and deca‐2(trans),4(trans)‐dienal [FL‐no: 05.140] were tested in vivo for the induction of micronuclei in rats bone marrow and peripheral reticulocytes after oral or intraperitoneal administration. None of the two substances induced increased frequencies of micronuclei. The Panel concluded that the concern for genotoxicity can be ruled out for the representative substances hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057] and deca‐2(trans),4(trans)‐dienal [FL‐no: 05.140] and therefore also for the other substances in this group [FL‐no: 02.139, 02.153, 02.162, 02.188, 05.064, 05.071, 05.081, 05.084, 05.101, 05.108, 05.125, 05.127, 05.141, 05.173, 05.186, 05.194, 05.196, 09.573]. These 20 substances can be evaluated using the Procedure for the evaluation of flavouring substances. |
format | Online Article Text |
id | pubmed-7009657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70096572020-07-02 Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds Silano, Vittorio Bolognesi, Claudia Castle, Laurence Chipman, Kevin Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Husøy, Trine Kärenlampi, Sirpa Mennes, Wim Milana, Maria Rosaria Pfaff, Karla Riviere, Gilles Srinivasan, Jannavi Tavares Poças, Maria de Fátima Tlustos, Christina Wölfle, Detlef Zorn, Holger Binderup, Mona‐Lise Marcon, Francesca Marzin, Daniel Mosesso, Pasquale Anastassiadou, Maria Carfì, Maria Gürtler, Rainer EFSA J Scientific Opinion The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of flavouring substances from subgroup 1.1.4 of FGE.19 in the Flavouring Group Evaluation 203 Revision 2 (FGE.203Rev2). In FGE. 203 Revision 1, the Panel concluded that the genotoxic potential could not be ruled out for the flavouring substances in this FGE. The Flavour Industry provided additional genotoxicity studies for the representative substances of FGE.19 subgroup 1.1.4, namely deca‐2(trans),4(trans)‐dienal [FL‐no: 05.140] and hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057]. In addition, new studies on hepta‐2,4‐dienal [FL‐no: 05.084], 2,4‐octadienal [FL‐no: 05.186] and tr‐2,tr‐4‐nonadienal [FL‐no: 05.194] were provided that are evaluated in the present revision of FGE.203, i.e. FGE.203Rev2. Hepta‐2,4‐dienal [FL‐no: 05.084], 2,4‐octadienal [FL‐no: 05.186] and tr‐2,tr‐4‐nonadienal [FL‐no: 05.194] did not induce gene mutations in bacteria. Hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057] did not induce gene mutations in vitro in mammalian cells. Hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057] was also tested in an in vivo gene mutation assay giving negative results. Both hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057] and deca‐2(trans),4(trans)‐dienal [FL‐no: 05.140] were tested in vivo for the induction of micronuclei in rats bone marrow and peripheral reticulocytes after oral or intraperitoneal administration. None of the two substances induced increased frequencies of micronuclei. The Panel concluded that the concern for genotoxicity can be ruled out for the representative substances hexa‐2(trans),4(trans)‐dienal [FL‐no: 05.057] and deca‐2(trans),4(trans)‐dienal [FL‐no: 05.140] and therefore also for the other substances in this group [FL‐no: 02.139, 02.153, 02.162, 02.188, 05.064, 05.071, 05.081, 05.084, 05.101, 05.108, 05.125, 05.127, 05.141, 05.173, 05.186, 05.194, 05.196, 09.573]. These 20 substances can be evaluated using the Procedure for the evaluation of flavouring substances. John Wiley and Sons Inc. 2018-07-20 /pmc/articles/PMC7009657/ /pubmed/32625963 http://dx.doi.org/10.2903/j.efsa.2018.5322 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Silano, Vittorio Bolognesi, Claudia Castle, Laurence Chipman, Kevin Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Husøy, Trine Kärenlampi, Sirpa Mennes, Wim Milana, Maria Rosaria Pfaff, Karla Riviere, Gilles Srinivasan, Jannavi Tavares Poças, Maria de Fátima Tlustos, Christina Wölfle, Detlef Zorn, Holger Binderup, Mona‐Lise Marcon, Francesca Marzin, Daniel Mosesso, Pasquale Anastassiadou, Maria Carfì, Maria Gürtler, Rainer Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds |
title | Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds |
title_full | Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds |
title_fullStr | Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds |
title_full_unstemmed | Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds |
title_short | Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds |
title_sort | scientific opinion on flavouring group evaluation 203, revision 2 (fge.203rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of fge.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009657/ https://www.ncbi.nlm.nih.gov/pubmed/32625963 http://dx.doi.org/10.2903/j.efsa.2018.5322 |
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