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Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms

Following a request from EFSA, the Panel on Plant Protection Products and their Residues (PPR) developed an opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) models and their use in prospective environmental risk assessment (ERA) for pesticides and aquatic organisms. TKTD models...

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Autores principales: Ockleford, Colin, Adriaanse, Paulien, Berny, Philippe, Brock, Theodorus, Duquesne, Sabine, Grilli, Sandro, Hernandez‐Jerez, Antonio F, Bennekou, Susanne Hougaard, Klein, Michael, Kuhl, Thomas, Laskowski, Ryszard, Machera, Kyriaki, Pelkonen, Olavi, Pieper, Silvia, Smith, Robert H, Stemmer, Michael, Sundh, Ingvar, Tiktak, Aaldrik, Topping, Christopher J., Wolterink, Gerrit, Cedergreen, Nina, Charles, Sandrine, Focks, Andreas, Reed, Melissa, Arena, Maria, Ippolito, Alessio, Byers, Harry, Teodorovic, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009662/
https://www.ncbi.nlm.nih.gov/pubmed/32626020
http://dx.doi.org/10.2903/j.efsa.2018.5377
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author Ockleford, Colin
Adriaanse, Paulien
Berny, Philippe
Brock, Theodorus
Duquesne, Sabine
Grilli, Sandro
Hernandez‐Jerez, Antonio F
Bennekou, Susanne Hougaard
Klein, Michael
Kuhl, Thomas
Laskowski, Ryszard
Machera, Kyriaki
Pelkonen, Olavi
Pieper, Silvia
Smith, Robert H
Stemmer, Michael
Sundh, Ingvar
Tiktak, Aaldrik
Topping, Christopher J.
Wolterink, Gerrit
Cedergreen, Nina
Charles, Sandrine
Focks, Andreas
Reed, Melissa
Arena, Maria
Ippolito, Alessio
Byers, Harry
Teodorovic, Ivana
author_facet Ockleford, Colin
Adriaanse, Paulien
Berny, Philippe
Brock, Theodorus
Duquesne, Sabine
Grilli, Sandro
Hernandez‐Jerez, Antonio F
Bennekou, Susanne Hougaard
Klein, Michael
Kuhl, Thomas
Laskowski, Ryszard
Machera, Kyriaki
Pelkonen, Olavi
Pieper, Silvia
Smith, Robert H
Stemmer, Michael
Sundh, Ingvar
Tiktak, Aaldrik
Topping, Christopher J.
Wolterink, Gerrit
Cedergreen, Nina
Charles, Sandrine
Focks, Andreas
Reed, Melissa
Arena, Maria
Ippolito, Alessio
Byers, Harry
Teodorovic, Ivana
collection PubMed
description Following a request from EFSA, the Panel on Plant Protection Products and their Residues (PPR) developed an opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) models and their use in prospective environmental risk assessment (ERA) for pesticides and aquatic organisms. TKTD models are species‐ and compound‐specific and can be used to predict (sub)lethal effects of pesticides under untested (time‐variable) exposure conditions. Three different types of TKTD models are described, viz., (i) the ‘General Unified Threshold models of Survival’ (GUTS), (ii) those based on the Dynamic Energy Budget theory (DEBtox models), and (iii) models for primary producers. All these TKTD models follow the principle that the processes influencing internal exposure of an organism, (TK), are separated from the processes that lead to damage and effects/mortality (TD). GUTS models can be used to predict survival rate under untested exposure conditions. DEBtox models explore the effects on growth and reproduction of toxicants over time, even over the entire life cycle. TKTD model for primary producers and pesticides have been developed for algae, Lemna and Myriophyllum. For all TKTD model calibration, both toxicity data on standard test species and/or additional species can be used. For validation, substance and species‐specific data sets from independent refined‐exposure experiments are required. Based on the current state of the art (e.g. lack of documented and evaluated examples), the DEBtox modelling approach is currently limited to research applications. However, its great potential for future use in prospective ERA for pesticides is recognised. The GUTS model and the Lemna model are considered ready to be used in risk assessment.
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spelling pubmed-70096622020-07-02 Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms Ockleford, Colin Adriaanse, Paulien Berny, Philippe Brock, Theodorus Duquesne, Sabine Grilli, Sandro Hernandez‐Jerez, Antonio F Bennekou, Susanne Hougaard Klein, Michael Kuhl, Thomas Laskowski, Ryszard Machera, Kyriaki Pelkonen, Olavi Pieper, Silvia Smith, Robert H Stemmer, Michael Sundh, Ingvar Tiktak, Aaldrik Topping, Christopher J. Wolterink, Gerrit Cedergreen, Nina Charles, Sandrine Focks, Andreas Reed, Melissa Arena, Maria Ippolito, Alessio Byers, Harry Teodorovic, Ivana EFSA J Scientific Opinion Following a request from EFSA, the Panel on Plant Protection Products and their Residues (PPR) developed an opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) models and their use in prospective environmental risk assessment (ERA) for pesticides and aquatic organisms. TKTD models are species‐ and compound‐specific and can be used to predict (sub)lethal effects of pesticides under untested (time‐variable) exposure conditions. Three different types of TKTD models are described, viz., (i) the ‘General Unified Threshold models of Survival’ (GUTS), (ii) those based on the Dynamic Energy Budget theory (DEBtox models), and (iii) models for primary producers. All these TKTD models follow the principle that the processes influencing internal exposure of an organism, (TK), are separated from the processes that lead to damage and effects/mortality (TD). GUTS models can be used to predict survival rate under untested exposure conditions. DEBtox models explore the effects on growth and reproduction of toxicants over time, even over the entire life cycle. TKTD model for primary producers and pesticides have been developed for algae, Lemna and Myriophyllum. For all TKTD model calibration, both toxicity data on standard test species and/or additional species can be used. For validation, substance and species‐specific data sets from independent refined‐exposure experiments are required. Based on the current state of the art (e.g. lack of documented and evaluated examples), the DEBtox modelling approach is currently limited to research applications. However, its great potential for future use in prospective ERA for pesticides is recognised. The GUTS model and the Lemna model are considered ready to be used in risk assessment. John Wiley and Sons Inc. 2018-08-23 /pmc/articles/PMC7009662/ /pubmed/32626020 http://dx.doi.org/10.2903/j.efsa.2018.5377 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Ockleford, Colin
Adriaanse, Paulien
Berny, Philippe
Brock, Theodorus
Duquesne, Sabine
Grilli, Sandro
Hernandez‐Jerez, Antonio F
Bennekou, Susanne Hougaard
Klein, Michael
Kuhl, Thomas
Laskowski, Ryszard
Machera, Kyriaki
Pelkonen, Olavi
Pieper, Silvia
Smith, Robert H
Stemmer, Michael
Sundh, Ingvar
Tiktak, Aaldrik
Topping, Christopher J.
Wolterink, Gerrit
Cedergreen, Nina
Charles, Sandrine
Focks, Andreas
Reed, Melissa
Arena, Maria
Ippolito, Alessio
Byers, Harry
Teodorovic, Ivana
Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms
title Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms
title_full Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms
title_fullStr Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms
title_full_unstemmed Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms
title_short Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms
title_sort scientific opinion on the state of the art of toxicokinetic/toxicodynamic (tktd) effect models for regulatory risk assessment of pesticides for aquatic organisms
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009662/
https://www.ncbi.nlm.nih.gov/pubmed/32626020
http://dx.doi.org/10.2903/j.efsa.2018.5377
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