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Safety and efficacy of vitamin B(2) (riboflavin) produced by Ashbya gossypii DSM 23096 for all animal species based on a dossier submitted by BASF SE
The European Commission asked EFSA for an opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of a riboflavin‐based additive (minimum 80%) produced by a genetically modified strain of Ashbya gossypii (DSM 23096). It is intended to be used in feed for...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009745/ https://www.ncbi.nlm.nih.gov/pubmed/32625973 http://dx.doi.org/10.2903/j.efsa.2018.5337 |
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author | Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wester, Pieter Costa, Lucio Dierick, Noël Glandorf, Boet Herman, Lieve Kärenlampi, Sirpa Leng, Lubomir Tebbe, Christoph Aguilera, Jaime Manini, Paola Tarrés‐Call, Jordi Wallace, Robert John |
author_facet | Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wester, Pieter Costa, Lucio Dierick, Noël Glandorf, Boet Herman, Lieve Kärenlampi, Sirpa Leng, Lubomir Tebbe, Christoph Aguilera, Jaime Manini, Paola Tarrés‐Call, Jordi Wallace, Robert John |
collection | PubMed |
description | The European Commission asked EFSA for an opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of a riboflavin‐based additive (minimum 80%) produced by a genetically modified strain of Ashbya gossypii (DSM 23096). It is intended to be used in feed for all animal species and categories. The additive under assessment does not give rise to safety concerns on the genetic modification of the production strain. The additive contains 80% of riboflavin (vitamin B(2)) and 20% of spent growth medium. The additive is safe for target animals with a wide margin of safety. The use of riboflavin 80% produced by A. gossypii DSM 23096 in animal nutrition does not represent a safety concern for consumers. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) cannot draw a final conclusion on the risk posed for the user by inhalation of riboflavin produced by A. gossypii DSM 23096 and on the potential to be irritant to skin or eyes. The product under assessment is not a skin sensitiser; however, riboflavin is a known photosensitiser. The use of riboflavin produced by A. gossypii DSM 23096 in animal nutrition does not pose a risk to the environment. The additive is regarded as an effective source of riboflavin in covering the animal's requirement when administered via feed. The FEEDAP Panel made recommendations on the description of the additive. |
format | Online Article Text |
id | pubmed-7009745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70097452020-07-02 Safety and efficacy of vitamin B(2) (riboflavin) produced by Ashbya gossypii DSM 23096 for all animal species based on a dossier submitted by BASF SE Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wester, Pieter Costa, Lucio Dierick, Noël Glandorf, Boet Herman, Lieve Kärenlampi, Sirpa Leng, Lubomir Tebbe, Christoph Aguilera, Jaime Manini, Paola Tarrés‐Call, Jordi Wallace, Robert John EFSA J Scientific Opinion The European Commission asked EFSA for an opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of a riboflavin‐based additive (minimum 80%) produced by a genetically modified strain of Ashbya gossypii (DSM 23096). It is intended to be used in feed for all animal species and categories. The additive under assessment does not give rise to safety concerns on the genetic modification of the production strain. The additive contains 80% of riboflavin (vitamin B(2)) and 20% of spent growth medium. The additive is safe for target animals with a wide margin of safety. The use of riboflavin 80% produced by A. gossypii DSM 23096 in animal nutrition does not represent a safety concern for consumers. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) cannot draw a final conclusion on the risk posed for the user by inhalation of riboflavin produced by A. gossypii DSM 23096 and on the potential to be irritant to skin or eyes. The product under assessment is not a skin sensitiser; however, riboflavin is a known photosensitiser. The use of riboflavin produced by A. gossypii DSM 23096 in animal nutrition does not pose a risk to the environment. The additive is regarded as an effective source of riboflavin in covering the animal's requirement when administered via feed. The FEEDAP Panel made recommendations on the description of the additive. John Wiley and Sons Inc. 2018-07-12 /pmc/articles/PMC7009745/ /pubmed/32625973 http://dx.doi.org/10.2903/j.efsa.2018.5337 Text en © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wester, Pieter Costa, Lucio Dierick, Noël Glandorf, Boet Herman, Lieve Kärenlampi, Sirpa Leng, Lubomir Tebbe, Christoph Aguilera, Jaime Manini, Paola Tarrés‐Call, Jordi Wallace, Robert John Safety and efficacy of vitamin B(2) (riboflavin) produced by Ashbya gossypii DSM 23096 for all animal species based on a dossier submitted by BASF SE |
title | Safety and efficacy of vitamin B(2) (riboflavin) produced by Ashbya gossypii
DSM 23096 for all animal species based on a dossier submitted by BASF SE
|
title_full | Safety and efficacy of vitamin B(2) (riboflavin) produced by Ashbya gossypii
DSM 23096 for all animal species based on a dossier submitted by BASF SE
|
title_fullStr | Safety and efficacy of vitamin B(2) (riboflavin) produced by Ashbya gossypii
DSM 23096 for all animal species based on a dossier submitted by BASF SE
|
title_full_unstemmed | Safety and efficacy of vitamin B(2) (riboflavin) produced by Ashbya gossypii
DSM 23096 for all animal species based on a dossier submitted by BASF SE
|
title_short | Safety and efficacy of vitamin B(2) (riboflavin) produced by Ashbya gossypii
DSM 23096 for all animal species based on a dossier submitted by BASF SE
|
title_sort | safety and efficacy of vitamin b(2) (riboflavin) produced by ashbya gossypii
dsm 23096 for all animal species based on a dossier submitted by basf se |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009745/ https://www.ncbi.nlm.nih.gov/pubmed/32625973 http://dx.doi.org/10.2903/j.efsa.2018.5337 |
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