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Safety and efficacy of ENZY CARBOPLUS (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species

ENZY CARBOPLUS (®) is an additive available in liquid and solid forms that contains endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase which are produced by two genetically modified strains of Komagataella pastoris. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) co...

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Autores principales: Rychen, Guido, Aquilina, Gabriele, Azimonti, Giovanna, Bampidis, Vasileios, Bastos, Maria de Lourdes, Bories, Georges, Chesson, Andrew, Flachowsky, Gerhard, Gropp, Jürgen, Kolar, Boris, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Mantovani, Alberto, Mayo, Baltasar, Ramos, Fernando, Saarela, Maria, Villa, Roberto Edoardo, Wallace, Robert John, Wester, Pieter, Brantom, Paul, Dierick, Noël Albert, Glandorf, Boet, Herman, Lieve, Tebbe, Christoph, Kärenlampi, Sirpa, Aguilera, Jaime, Anguita, Montserrat, Cocconcelli, Pier Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009843/
https://www.ncbi.nlm.nih.gov/pubmed/32625383
http://dx.doi.org/10.2903/j.efsa.2017.5097
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author Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Dierick, Noël Albert
Glandorf, Boet
Herman, Lieve
Tebbe, Christoph
Kärenlampi, Sirpa
Aguilera, Jaime
Anguita, Montserrat
Cocconcelli, Pier Sandro
author_facet Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Dierick, Noël Albert
Glandorf, Boet
Herman, Lieve
Tebbe, Christoph
Kärenlampi, Sirpa
Aguilera, Jaime
Anguita, Montserrat
Cocconcelli, Pier Sandro
collection PubMed
description ENZY CARBOPLUS (®) is an additive available in liquid and solid forms that contains endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase which are produced by two genetically modified strains of Komagataella pastoris. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the production strains are safe and the genetic modifications raise no safety concerns. The Panel also concluded that the additive is safe for the target species at the recommended dosages and that its use as a feed additive raises no concern for consumers. The additive in either form is not a skin or eye irritant nor a dermal sensitiser; however, it is considered as a potential respiratory sensitiser. The production strains and their recombinant DNA were not detectable in the additive; moreover, the active substances of the additive will be degraded/inactivated during passage through the digestive tract of animals or in the environment, consequently, the Panel concluded that the additive poses no concerns to the environment. The Panel concluded that the additive has a potential to be efficacious as a zootechnical additive in chickens for fattening at 4,000 LXU and 375 LGU per kg feed, in turkeys for fattening at 1,400 LXU and 120 LGU per kg feed, and in weaned piglets at 700 LXU and 60 LGU per kg feed. The Panel extended these conclusions to chickens reared for laying and turkeys reared for breeding at the corresponding doses. Since the mode of action of xylanase and glucanase can be reasonably assumed to be the same within avian or within porcine species, the Panel extrapolated the conclusions on the efficacy to all avian species up to the point of lay and to all porcine species. Owing to the lack of data, no conclusions could be drawn on the efficacy of the additive in laying hens.
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spelling pubmed-70098432020-07-02 Safety and efficacy of ENZY CARBOPLUS (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brantom, Paul Dierick, Noël Albert Glandorf, Boet Herman, Lieve Tebbe, Christoph Kärenlampi, Sirpa Aguilera, Jaime Anguita, Montserrat Cocconcelli, Pier Sandro EFSA J Scientific Opinion ENZY CARBOPLUS (®) is an additive available in liquid and solid forms that contains endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase which are produced by two genetically modified strains of Komagataella pastoris. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the production strains are safe and the genetic modifications raise no safety concerns. The Panel also concluded that the additive is safe for the target species at the recommended dosages and that its use as a feed additive raises no concern for consumers. The additive in either form is not a skin or eye irritant nor a dermal sensitiser; however, it is considered as a potential respiratory sensitiser. The production strains and their recombinant DNA were not detectable in the additive; moreover, the active substances of the additive will be degraded/inactivated during passage through the digestive tract of animals or in the environment, consequently, the Panel concluded that the additive poses no concerns to the environment. The Panel concluded that the additive has a potential to be efficacious as a zootechnical additive in chickens for fattening at 4,000 LXU and 375 LGU per kg feed, in turkeys for fattening at 1,400 LXU and 120 LGU per kg feed, and in weaned piglets at 700 LXU and 60 LGU per kg feed. The Panel extended these conclusions to chickens reared for laying and turkeys reared for breeding at the corresponding doses. Since the mode of action of xylanase and glucanase can be reasonably assumed to be the same within avian or within porcine species, the Panel extrapolated the conclusions on the efficacy to all avian species up to the point of lay and to all porcine species. Owing to the lack of data, no conclusions could be drawn on the efficacy of the additive in laying hens. John Wiley and Sons Inc. 2017-12-21 /pmc/articles/PMC7009843/ /pubmed/32625383 http://dx.doi.org/10.2903/j.efsa.2017.5097 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Dierick, Noël Albert
Glandorf, Boet
Herman, Lieve
Tebbe, Christoph
Kärenlampi, Sirpa
Aguilera, Jaime
Anguita, Montserrat
Cocconcelli, Pier Sandro
Safety and efficacy of ENZY CARBOPLUS (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species
title Safety and efficacy of ENZY CARBOPLUS (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species
title_full Safety and efficacy of ENZY CARBOPLUS (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species
title_fullStr Safety and efficacy of ENZY CARBOPLUS (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species
title_full_unstemmed Safety and efficacy of ENZY CARBOPLUS (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species
title_short Safety and efficacy of ENZY CARBOPLUS (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species
title_sort safety and efficacy of enzy carboplus (®) (endo‐1,4‐beta‐xylanase and endo‐1,3(4)‐beta‐glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009843/
https://www.ncbi.nlm.nih.gov/pubmed/32625383
http://dx.doi.org/10.2903/j.efsa.2017.5097
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