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Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Glycomer GmbH
The additive cassia gum consists mainly of high‐molecular weight polysaccharides composed primarily of a linear chain of 1,4‐β‐d‐mannopyranose units with 1,6‐linked α‐d‐galactopyranose units. In 2014, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) delivered an opinion...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009862/ https://www.ncbi.nlm.nih.gov/pubmed/32625411 http://dx.doi.org/10.2903/j.efsa.2017.4710 |
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author | Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen |
author_facet | Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen |
collection | PubMed |
description | The additive cassia gum consists mainly of high‐molecular weight polysaccharides composed primarily of a linear chain of 1,4‐β‐d‐mannopyranose units with 1,6‐linked α‐d‐galactopyranose units. In 2014, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) delivered an opinion on the safety and efficacy of cassia gum. The FEEDAP Panel concluded, based on positive findings observed in a bacterial reverse mutation test with a semirefined cassia gum (about 70 mg anthraquinones/kg) but not with purified semirefined cassia gum that meets the specification as a food additive (< 0.5 mg anthraquinones/kg), that only purified semirefined cassia gum that meets the specifications of cassia gum as a food additive can be considered safe for cats and dogs, at a maximum content of 1.5% cassia gum (15,000 mg/kg feed) in dry matter, corresponding to 1.32% (13,200 mg/kg feed) in a standardised complete feed with 12% water content. The FEEDAP Panel also concluded that cassia gum should be regarded as a skin and respiratory sensitiser and as a potential irritant to skin and eyes. Following this opinion, the European Commission gave the possibility to the applicant to submit complementary information on the safety for all animal species. No new data were submitted to address the potential of the additive to exert mutagenic effects, and therefore, the FEEDAP Panel is not in the position to modify the conclusions reached in the previous opinion. |
format | Online Article Text |
id | pubmed-7009862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70098622020-07-02 Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Glycomer GmbH Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen EFSA J Scientific Opinion The additive cassia gum consists mainly of high‐molecular weight polysaccharides composed primarily of a linear chain of 1,4‐β‐d‐mannopyranose units with 1,6‐linked α‐d‐galactopyranose units. In 2014, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) delivered an opinion on the safety and efficacy of cassia gum. The FEEDAP Panel concluded, based on positive findings observed in a bacterial reverse mutation test with a semirefined cassia gum (about 70 mg anthraquinones/kg) but not with purified semirefined cassia gum that meets the specification as a food additive (< 0.5 mg anthraquinones/kg), that only purified semirefined cassia gum that meets the specifications of cassia gum as a food additive can be considered safe for cats and dogs, at a maximum content of 1.5% cassia gum (15,000 mg/kg feed) in dry matter, corresponding to 1.32% (13,200 mg/kg feed) in a standardised complete feed with 12% water content. The FEEDAP Panel also concluded that cassia gum should be regarded as a skin and respiratory sensitiser and as a potential irritant to skin and eyes. Following this opinion, the European Commission gave the possibility to the applicant to submit complementary information on the safety for all animal species. No new data were submitted to address the potential of the additive to exert mutagenic effects, and therefore, the FEEDAP Panel is not in the position to modify the conclusions reached in the previous opinion. John Wiley and Sons Inc. 2017-02-23 /pmc/articles/PMC7009862/ /pubmed/32625411 http://dx.doi.org/10.2903/j.efsa.2017.4710 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Glycomer GmbH |
title | Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Glycomer GmbH |
title_full | Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Glycomer GmbH |
title_fullStr | Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Glycomer GmbH |
title_full_unstemmed | Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Glycomer GmbH |
title_short | Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Glycomer GmbH |
title_sort | safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by glycomer gmbh |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009862/ https://www.ncbi.nlm.nih.gov/pubmed/32625411 http://dx.doi.org/10.2903/j.efsa.2017.4710 |
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