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Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Intercolloid (UK) Ltd

The additive cassia gum consists mainly of high‐molecular weight polysaccharides composed primarily of a linear chain of 1,4‐β‐d‐mannopyranose units with 1,6‐linked α‐d‐galactopyranose units. In 2014, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) delivered an opinion...

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Autores principales: Rychen, Guido, Aquilina, Gabriele, Azimonti, Giovanna, Bampidis, Vasileios, Bastos, Maria de Lourdes, Bories, Georges, Chesson, Andrew, Cocconcelli, Pier Sandro, Flachowsky, Gerhard, Kolar, Boris, Kouba, Maryline, López Puente, Secundino, López‐Alonso, Marta, Mantovani, Alberto, Mayo, Baltasar, Ramos, Fernando, Saarela, Maria, Villa, Roberto Edoardo, Wallace, Robert John, Wester, Pieter, Lundebye, Anne‐Katrine, Nebbia, Carlo, Renshaw, Derek, Innocenti, Matteo Lorenzo, Gropp, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009868/
https://www.ncbi.nlm.nih.gov/pubmed/32625410
http://dx.doi.org/10.2903/j.efsa.2017.4709
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author Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Lundebye, Anne‐Katrine
Nebbia, Carlo
Renshaw, Derek
Innocenti, Matteo Lorenzo
Gropp, Jürgen
author_facet Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Lundebye, Anne‐Katrine
Nebbia, Carlo
Renshaw, Derek
Innocenti, Matteo Lorenzo
Gropp, Jürgen
collection PubMed
description The additive cassia gum consists mainly of high‐molecular weight polysaccharides composed primarily of a linear chain of 1,4‐β‐d‐mannopyranose units with 1,6‐linked α‐d‐galactopyranose units. In 2014, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) delivered an opinion on the safety and efficacy of cassia gum. The FEEDAP Panel concluded, based on positive findings observed in a bacterial reverse mutation test with a semirefined cassia gum (about 70 mg anthraquinones/kg) but not with purified semirefined cassia gum that meets the specification as a food additive (< 0.5 mg anthraquinones/kg), that only purified semirefined cassia gum that meets the specifications of cassia gum as a food additive can be considered safe for cats and dogs, at a maximum content of 1.5% cassia gum (15,000 mg/kg feed) in dry matter, corresponding to 1.32% (13,200 mg/kg feed) in a standardised complete feed with 12% water content. Following this opinion, the European Commission gave the possibility to the applicant to submit complementary information in order to complete the assessment on the safety for all animal species. The new data submitted, describing a reproduction study in cats, do not address the potential of the additive to exert mutagenic effects, and do not allow conclusions to be drawn on the safety of semirefined cassia gum with an anthraquinone content higher than the one specified for the use as a food additive (< 0.5 mg/kg). The FEEDAP Panel is not in the position to modify the conclusions reached in the previous opinion.
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spelling pubmed-70098682020-07-02 Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Intercolloid (UK) Ltd Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Kolar, Boris Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Lundebye, Anne‐Katrine Nebbia, Carlo Renshaw, Derek Innocenti, Matteo Lorenzo Gropp, Jürgen EFSA J Scientific Opinion The additive cassia gum consists mainly of high‐molecular weight polysaccharides composed primarily of a linear chain of 1,4‐β‐d‐mannopyranose units with 1,6‐linked α‐d‐galactopyranose units. In 2014, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) delivered an opinion on the safety and efficacy of cassia gum. The FEEDAP Panel concluded, based on positive findings observed in a bacterial reverse mutation test with a semirefined cassia gum (about 70 mg anthraquinones/kg) but not with purified semirefined cassia gum that meets the specification as a food additive (< 0.5 mg anthraquinones/kg), that only purified semirefined cassia gum that meets the specifications of cassia gum as a food additive can be considered safe for cats and dogs, at a maximum content of 1.5% cassia gum (15,000 mg/kg feed) in dry matter, corresponding to 1.32% (13,200 mg/kg feed) in a standardised complete feed with 12% water content. Following this opinion, the European Commission gave the possibility to the applicant to submit complementary information in order to complete the assessment on the safety for all animal species. The new data submitted, describing a reproduction study in cats, do not address the potential of the additive to exert mutagenic effects, and do not allow conclusions to be drawn on the safety of semirefined cassia gum with an anthraquinone content higher than the one specified for the use as a food additive (< 0.5 mg/kg). The FEEDAP Panel is not in the position to modify the conclusions reached in the previous opinion. John Wiley and Sons Inc. 2017-02-08 /pmc/articles/PMC7009868/ /pubmed/32625410 http://dx.doi.org/10.2903/j.efsa.2017.4709 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Kolar, Boris
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Lundebye, Anne‐Katrine
Nebbia, Carlo
Renshaw, Derek
Innocenti, Matteo Lorenzo
Gropp, Jürgen
Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Intercolloid (UK) Ltd
title Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Intercolloid (UK) Ltd
title_full Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Intercolloid (UK) Ltd
title_fullStr Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Intercolloid (UK) Ltd
title_full_unstemmed Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Intercolloid (UK) Ltd
title_short Safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by Intercolloid (UK) Ltd
title_sort safety of cassia gum as a feed additive for dogs and cats based on a dossier submitted by intercolloid (uk) ltd
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009868/
https://www.ncbi.nlm.nih.gov/pubmed/32625410
http://dx.doi.org/10.2903/j.efsa.2017.4709
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