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Safety and efficacy of l‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species

The product subject of this assessment is l‐threonine produced by fermentation with a genetically modified strain of Escherichia coli (CGMCC 11473). It is intended to be used in feed and water for drinking for all animal species and categories. It was not possible to characterise the genetic modific...

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Autores principales: Rychen, Guido, Aquilina, Gabriele, Azimonti, Giovanna, Bampidis, Vasileios, Bastos, Maria de Lourdes, Bories, Georges, Chesson, Andrew, Cocconcelli, Pier Sandro, Flachowsky, Gerhard, Gropp, Jürgen, Kolar, Boris, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Mantovani, Alberto, Mayo, Baltasar, Ramos, Fernando, Saarela, Maria, Villa, Roberto Edoardo, Wester, Pieter, Costa, Lucio, Dierick, Noël, Leng, Lubomir, Glandorf, Boet, Herman, Lieve, Kärenlampi, Sirpa, Aguilera, Jaime, Tarrés‐Call, Jordi, Wallace, Robert John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009872/
https://www.ncbi.nlm.nih.gov/pubmed/32625592
http://dx.doi.org/10.2903/j.efsa.2017.4939
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author Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wester, Pieter
Costa, Lucio
Dierick, Noël
Leng, Lubomir
Glandorf, Boet
Herman, Lieve
Kärenlampi, Sirpa
Aguilera, Jaime
Tarrés‐Call, Jordi
Wallace, Robert John
author_facet Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wester, Pieter
Costa, Lucio
Dierick, Noël
Leng, Lubomir
Glandorf, Boet
Herman, Lieve
Kärenlampi, Sirpa
Aguilera, Jaime
Tarrés‐Call, Jordi
Wallace, Robert John
collection PubMed
description The product subject of this assessment is l‐threonine produced by fermentation with a genetically modified strain of Escherichia coli (CGMCC 11473). It is intended to be used in feed and water for drinking for all animal species and categories. It was not possible to characterise the genetic modification with the information provided. Uncertainty remained on the possible presence of cells from the production strain and their recombinant DNA in the product. Therefore, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the safety of the product l‐threonine, produced by fermentation with Escherichia coli CGMCC 11473 for the target species, consumers and the environment. The FEEDAP Panel has concerns on the safety of the simultaneous oral administration of threonine containing additives via water for drinking and feed. In the absence of data, the FEEDAP Panel cannot conclude on the potential of the additive to be an irritant for skin and eyes or to be a skin sensitiser. There is a risk from the exposure by inhalation to endotoxins for persons handling the additive. The product under assessment is considered an efficacious source of the amino acid l‐threonine for all animal species. For l‐threonine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.
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spelling pubmed-70098722020-07-02 Safety and efficacy of l‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wester, Pieter Costa, Lucio Dierick, Noël Leng, Lubomir Glandorf, Boet Herman, Lieve Kärenlampi, Sirpa Aguilera, Jaime Tarrés‐Call, Jordi Wallace, Robert John EFSA J Scientific Opinion The product subject of this assessment is l‐threonine produced by fermentation with a genetically modified strain of Escherichia coli (CGMCC 11473). It is intended to be used in feed and water for drinking for all animal species and categories. It was not possible to characterise the genetic modification with the information provided. Uncertainty remained on the possible presence of cells from the production strain and their recombinant DNA in the product. Therefore, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the safety of the product l‐threonine, produced by fermentation with Escherichia coli CGMCC 11473 for the target species, consumers and the environment. The FEEDAP Panel has concerns on the safety of the simultaneous oral administration of threonine containing additives via water for drinking and feed. In the absence of data, the FEEDAP Panel cannot conclude on the potential of the additive to be an irritant for skin and eyes or to be a skin sensitiser. There is a risk from the exposure by inhalation to endotoxins for persons handling the additive. The product under assessment is considered an efficacious source of the amino acid l‐threonine for all animal species. For l‐threonine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen. John Wiley and Sons Inc. 2017-07-25 /pmc/articles/PMC7009872/ /pubmed/32625592 http://dx.doi.org/10.2903/j.efsa.2017.4939 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Chesson, Andrew
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wester, Pieter
Costa, Lucio
Dierick, Noël
Leng, Lubomir
Glandorf, Boet
Herman, Lieve
Kärenlampi, Sirpa
Aguilera, Jaime
Tarrés‐Call, Jordi
Wallace, Robert John
Safety and efficacy of l‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species
title Safety and efficacy of l‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species
title_full Safety and efficacy of l‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species
title_fullStr Safety and efficacy of l‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species
title_full_unstemmed Safety and efficacy of l‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species
title_short Safety and efficacy of l‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species
title_sort safety and efficacy of l‐threonine produced by fermentation with escherichia coli cgmcc 11473 for all animal species
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009872/
https://www.ncbi.nlm.nih.gov/pubmed/32625592
http://dx.doi.org/10.2903/j.efsa.2017.4939
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