Cargando…
Re‐evaluation of tragacanth (E 413) as a food additive
The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re‐evaluating the safety of tragacanth (E 413) as a food additive. In the EU, tragacanth (E 413) has been evaluated by the Scientific Committee for Food (SCF, 1989) and by the Joint FAO/WHO Expert Comm...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009969/ https://www.ncbi.nlm.nih.gov/pubmed/32625506 http://dx.doi.org/10.2903/j.efsa.2017.4789 |
_version_ | 1783495782245072896 |
---|---|
author | Mortensen, Alicja Aguilar, Fernando Crebelli, Riccardo Di Domenico, Alessandro Frutos, Maria Jose Galtier, Pierre Gott, David Gundert‐Remy, Ursula Lambré, Claude Leblanc, Jean‐Charles Lindtner, Oliver Moldeus, Peter Mosesso, Pasquale Oskarsson, Agneta Parent‐Massin, Dominique Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Younes, Maged Brimer, Leon Christodoulidou, Anna Lodi, Federica Gelgelova, Petra Dusemund, Birgit |
author_facet | Mortensen, Alicja Aguilar, Fernando Crebelli, Riccardo Di Domenico, Alessandro Frutos, Maria Jose Galtier, Pierre Gott, David Gundert‐Remy, Ursula Lambré, Claude Leblanc, Jean‐Charles Lindtner, Oliver Moldeus, Peter Mosesso, Pasquale Oskarsson, Agneta Parent‐Massin, Dominique Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Younes, Maged Brimer, Leon Christodoulidou, Anna Lodi, Federica Gelgelova, Petra Dusemund, Birgit |
collection | PubMed |
description | The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re‐evaluating the safety of tragacanth (E 413) as a food additive. In the EU, tragacanth (E 413) has been evaluated by the Scientific Committee for Food (SCF, 1989) and by the Joint FAO/WHO Expert Committee on Food Additives (JECFA, 1987), who both allocated an acceptable daily intake (ADI) ‘not specified’ for this gum. Following the conceptual framework for the risk assessment of certain food additives, re‐evaluated under Commission Regulation (EU) No 257/2010, the Panel considered that adequate exposure and toxicity data were available. Tragacanth (E 413) is unlikely to be absorbed intact and is partially fermented by intestinal microbiota. No adverse effects were reported in carcinogenicity studies at the highest dose tested and there is no concern with respect to the genotoxicity. Oral daily intake of a large amount of tragacanth up to 9,900 mg tragacanth/person per day (approximately equivalent 141 mg tragacanth/kg body weight (bw) per day) for up to 21 days was well tolerated in humans. The Panel concluded that there is no need for a numerical ADI for tragacanth (E 413) and that there is no safety concern for the general population at the refined exposure assessment of tragacanth (E 413) as a food additive at the reported uses and use levels. |
format | Online Article Text |
id | pubmed-7009969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70099692020-07-02 Re‐evaluation of tragacanth (E 413) as a food additive Mortensen, Alicja Aguilar, Fernando Crebelli, Riccardo Di Domenico, Alessandro Frutos, Maria Jose Galtier, Pierre Gott, David Gundert‐Remy, Ursula Lambré, Claude Leblanc, Jean‐Charles Lindtner, Oliver Moldeus, Peter Mosesso, Pasquale Oskarsson, Agneta Parent‐Massin, Dominique Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Younes, Maged Brimer, Leon Christodoulidou, Anna Lodi, Federica Gelgelova, Petra Dusemund, Birgit EFSA J Scientific Opinion The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re‐evaluating the safety of tragacanth (E 413) as a food additive. In the EU, tragacanth (E 413) has been evaluated by the Scientific Committee for Food (SCF, 1989) and by the Joint FAO/WHO Expert Committee on Food Additives (JECFA, 1987), who both allocated an acceptable daily intake (ADI) ‘not specified’ for this gum. Following the conceptual framework for the risk assessment of certain food additives, re‐evaluated under Commission Regulation (EU) No 257/2010, the Panel considered that adequate exposure and toxicity data were available. Tragacanth (E 413) is unlikely to be absorbed intact and is partially fermented by intestinal microbiota. No adverse effects were reported in carcinogenicity studies at the highest dose tested and there is no concern with respect to the genotoxicity. Oral daily intake of a large amount of tragacanth up to 9,900 mg tragacanth/person per day (approximately equivalent 141 mg tragacanth/kg body weight (bw) per day) for up to 21 days was well tolerated in humans. The Panel concluded that there is no need for a numerical ADI for tragacanth (E 413) and that there is no safety concern for the general population at the refined exposure assessment of tragacanth (E 413) as a food additive at the reported uses and use levels. John Wiley and Sons Inc. 2017-06-09 /pmc/articles/PMC7009969/ /pubmed/32625506 http://dx.doi.org/10.2903/j.efsa.2017.4789 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Mortensen, Alicja Aguilar, Fernando Crebelli, Riccardo Di Domenico, Alessandro Frutos, Maria Jose Galtier, Pierre Gott, David Gundert‐Remy, Ursula Lambré, Claude Leblanc, Jean‐Charles Lindtner, Oliver Moldeus, Peter Mosesso, Pasquale Oskarsson, Agneta Parent‐Massin, Dominique Stankovic, Ivan Waalkens‐Berendsen, Ine Woutersen, Rudolf Antonius Wright, Matthew Younes, Maged Brimer, Leon Christodoulidou, Anna Lodi, Federica Gelgelova, Petra Dusemund, Birgit Re‐evaluation of tragacanth (E 413) as a food additive |
title | Re‐evaluation of tragacanth (E 413) as a food additive |
title_full | Re‐evaluation of tragacanth (E 413) as a food additive |
title_fullStr | Re‐evaluation of tragacanth (E 413) as a food additive |
title_full_unstemmed | Re‐evaluation of tragacanth (E 413) as a food additive |
title_short | Re‐evaluation of tragacanth (E 413) as a food additive |
title_sort | re‐evaluation of tragacanth (e 413) as a food additive |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009969/ https://www.ncbi.nlm.nih.gov/pubmed/32625506 http://dx.doi.org/10.2903/j.efsa.2017.4789 |
work_keys_str_mv | AT reevaluationoftragacanthe413asafoodadditive AT mortensenalicja reevaluationoftragacanthe413asafoodadditive AT aguilarfernando reevaluationoftragacanthe413asafoodadditive AT crebelliriccardo reevaluationoftragacanthe413asafoodadditive AT didomenicoalessandro reevaluationoftragacanthe413asafoodadditive AT frutosmariajose reevaluationoftragacanthe413asafoodadditive AT galtierpierre reevaluationoftragacanthe413asafoodadditive AT gottdavid reevaluationoftragacanthe413asafoodadditive AT gundertremyursula reevaluationoftragacanthe413asafoodadditive AT lambreclaude reevaluationoftragacanthe413asafoodadditive AT leblancjeancharles reevaluationoftragacanthe413asafoodadditive AT lindtneroliver reevaluationoftragacanthe413asafoodadditive AT moldeuspeter reevaluationoftragacanthe413asafoodadditive AT mosessopasquale reevaluationoftragacanthe413asafoodadditive AT oskarssonagneta reevaluationoftragacanthe413asafoodadditive AT parentmassindominique reevaluationoftragacanthe413asafoodadditive AT stankovicivan reevaluationoftragacanthe413asafoodadditive AT waalkensberendsenine reevaluationoftragacanthe413asafoodadditive AT woutersenrudolfantonius reevaluationoftragacanthe413asafoodadditive AT wrightmatthew reevaluationoftragacanthe413asafoodadditive AT younesmaged reevaluationoftragacanthe413asafoodadditive AT brimerleon reevaluationoftragacanthe413asafoodadditive AT christodoulidouanna reevaluationoftragacanthe413asafoodadditive AT lodifederica reevaluationoftragacanthe413asafoodadditive AT gelgelovapetra reevaluationoftragacanthe413asafoodadditive AT dusemundbirgit reevaluationoftragacanthe413asafoodadditive |