Cargando…

Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to deliver a scientific opinion on the implications for human health of the flavouring rum ether [FL‐no: 21.001] in the Flavouring Group Evaluation 500 (FGE.500), accordi...

Descripción completa

Detalles Bibliográficos
Autores principales: Silano, Vittorio, Bolognesi, Claudia, Castle, Laurence, Cravedi, Jean‐Pierre, Engel, Karl‐Heinz, Fowler, Paul, Franz, Roland, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kärenlampi, Sirpa, Milana, Maria Rosaria, Penninks, André, Tavares Poças, Maria de Fátima, Smith, Andrew, Tlustos, Christina, Wölfle, Detlef, Zorn, Holger, Zugravu, Corina‐Aurelia, Beckman Sundh, Ulla, Benigni, Romualdo, Brimer, Leon, Mulder, Gerard, Oskarsson, Agneta, Svendsen, Camilla, Martino, Carla, Mennes, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010020/
https://www.ncbi.nlm.nih.gov/pubmed/32625610
http://dx.doi.org/10.2903/j.efsa.2017.4897
_version_ 1783495794205130752
author Silano, Vittorio
Bolognesi, Claudia
Castle, Laurence
Cravedi, Jean‐Pierre
Engel, Karl‐Heinz
Fowler, Paul
Franz, Roland
Grob, Konrad
Gürtler, Rainer
Husøy, Trine
Kärenlampi, Sirpa
Milana, Maria Rosaria
Penninks, André
Tavares Poças, Maria de Fátima
Smith, Andrew
Tlustos, Christina
Wölfle, Detlef
Zorn, Holger
Zugravu, Corina‐Aurelia
Beckman Sundh, Ulla
Benigni, Romualdo
Brimer, Leon
Mulder, Gerard
Oskarsson, Agneta
Svendsen, Camilla
Martino, Carla
Mennes, Wim
author_facet Silano, Vittorio
Bolognesi, Claudia
Castle, Laurence
Cravedi, Jean‐Pierre
Engel, Karl‐Heinz
Fowler, Paul
Franz, Roland
Grob, Konrad
Gürtler, Rainer
Husøy, Trine
Kärenlampi, Sirpa
Milana, Maria Rosaria
Penninks, André
Tavares Poças, Maria de Fátima
Smith, Andrew
Tlustos, Christina
Wölfle, Detlef
Zorn, Holger
Zugravu, Corina‐Aurelia
Beckman Sundh, Ulla
Benigni, Romualdo
Brimer, Leon
Mulder, Gerard
Oskarsson, Agneta
Svendsen, Camilla
Martino, Carla
Mennes, Wim
collection PubMed
description The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to deliver a scientific opinion on the implications for human health of the flavouring rum ether [FL‐no: 21.001] in the Flavouring Group Evaluation 500 (FGE.500), according to Regulation (EC) No 1331/2008 and Regulation (EC) No 1334/2008 of the European Parliament and of the Council. Rum ether is a complex mixture of volatile substances obtained by distillation of the reaction products of pyroligneous acid and ethyl alcohol under oxidative conditions in the presence of manganese dioxide and sulfuric acid. A total of 84 volatile constituents have been reported by the applicant. It is a colourless liquid with a rum‐like odour and flavour. Its major uses are in the food categories beverages, confectionery and baked goods. The Panel decided to apply a congeneric group‐based approach. The 84 reported constituents were allocated to 12 congeneric groups, based on structural and metabolic similarity. For eight of the congeneric groups, the Panel concluded that there is no safety concern at the intended conditions of use. However, the Panel concluded that substances in congeneric group 1 (ethanol and acetaldehyde) and congeneric group 12 (furan) are carcinogenic and genotoxic. The Panel also identified genotoxicity concerns for substances in congeneric group 3 (3‐pentene‐2‐one). The exposure for congeneric group 10 (ethers of various structures) was above the Threshold of Toxicological Concern (TTC) applicable for this group, but a point of departure or health based guidance value that covers all the substances in this group could not be identified. The Panel concluded that according to the overall strategy for the risk assessment of flavouring substances, the presence of genotoxic substances as process‐derived constituents of rum ether is of safety concern.
format Online
Article
Text
id pubmed-7010020
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-70100202020-07-02 Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether Silano, Vittorio Bolognesi, Claudia Castle, Laurence Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Gürtler, Rainer Husøy, Trine Kärenlampi, Sirpa Milana, Maria Rosaria Penninks, André Tavares Poças, Maria de Fátima Smith, Andrew Tlustos, Christina Wölfle, Detlef Zorn, Holger Zugravu, Corina‐Aurelia Beckman Sundh, Ulla Benigni, Romualdo Brimer, Leon Mulder, Gerard Oskarsson, Agneta Svendsen, Camilla Martino, Carla Mennes, Wim EFSA J Scientific Opinion The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to deliver a scientific opinion on the implications for human health of the flavouring rum ether [FL‐no: 21.001] in the Flavouring Group Evaluation 500 (FGE.500), according to Regulation (EC) No 1331/2008 and Regulation (EC) No 1334/2008 of the European Parliament and of the Council. Rum ether is a complex mixture of volatile substances obtained by distillation of the reaction products of pyroligneous acid and ethyl alcohol under oxidative conditions in the presence of manganese dioxide and sulfuric acid. A total of 84 volatile constituents have been reported by the applicant. It is a colourless liquid with a rum‐like odour and flavour. Its major uses are in the food categories beverages, confectionery and baked goods. The Panel decided to apply a congeneric group‐based approach. The 84 reported constituents were allocated to 12 congeneric groups, based on structural and metabolic similarity. For eight of the congeneric groups, the Panel concluded that there is no safety concern at the intended conditions of use. However, the Panel concluded that substances in congeneric group 1 (ethanol and acetaldehyde) and congeneric group 12 (furan) are carcinogenic and genotoxic. The Panel also identified genotoxicity concerns for substances in congeneric group 3 (3‐pentene‐2‐one). The exposure for congeneric group 10 (ethers of various structures) was above the Threshold of Toxicological Concern (TTC) applicable for this group, but a point of departure or health based guidance value that covers all the substances in this group could not be identified. The Panel concluded that according to the overall strategy for the risk assessment of flavouring substances, the presence of genotoxic substances as process‐derived constituents of rum ether is of safety concern. John Wiley and Sons Inc. 2017-08-24 /pmc/articles/PMC7010020/ /pubmed/32625610 http://dx.doi.org/10.2903/j.efsa.2017.4897 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Silano, Vittorio
Bolognesi, Claudia
Castle, Laurence
Cravedi, Jean‐Pierre
Engel, Karl‐Heinz
Fowler, Paul
Franz, Roland
Grob, Konrad
Gürtler, Rainer
Husøy, Trine
Kärenlampi, Sirpa
Milana, Maria Rosaria
Penninks, André
Tavares Poças, Maria de Fátima
Smith, Andrew
Tlustos, Christina
Wölfle, Detlef
Zorn, Holger
Zugravu, Corina‐Aurelia
Beckman Sundh, Ulla
Benigni, Romualdo
Brimer, Leon
Mulder, Gerard
Oskarsson, Agneta
Svendsen, Camilla
Martino, Carla
Mennes, Wim
Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether
title Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether
title_full Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether
title_fullStr Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether
title_full_unstemmed Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether
title_short Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether
title_sort scientific opinion of flavouring group evaluation 500 (fge.500): rum ether
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010020/
https://www.ncbi.nlm.nih.gov/pubmed/32625610
http://dx.doi.org/10.2903/j.efsa.2017.4897
work_keys_str_mv AT scientificopinionofflavouringgroupevaluation500fge500rumether
AT silanovittorio scientificopinionofflavouringgroupevaluation500fge500rumether
AT bolognesiclaudia scientificopinionofflavouringgroupevaluation500fge500rumether
AT castlelaurence scientificopinionofflavouringgroupevaluation500fge500rumether
AT cravedijeanpierre scientificopinionofflavouringgroupevaluation500fge500rumether
AT engelkarlheinz scientificopinionofflavouringgroupevaluation500fge500rumether
AT fowlerpaul scientificopinionofflavouringgroupevaluation500fge500rumether
AT franzroland scientificopinionofflavouringgroupevaluation500fge500rumether
AT grobkonrad scientificopinionofflavouringgroupevaluation500fge500rumether
AT gurtlerrainer scientificopinionofflavouringgroupevaluation500fge500rumether
AT husøytrine scientificopinionofflavouringgroupevaluation500fge500rumether
AT karenlampisirpa scientificopinionofflavouringgroupevaluation500fge500rumether
AT milanamariarosaria scientificopinionofflavouringgroupevaluation500fge500rumether
AT penninksandre scientificopinionofflavouringgroupevaluation500fge500rumether
AT tavarespocasmariadefatima scientificopinionofflavouringgroupevaluation500fge500rumether
AT smithandrew scientificopinionofflavouringgroupevaluation500fge500rumether
AT tlustoschristina scientificopinionofflavouringgroupevaluation500fge500rumether
AT wolfledetlef scientificopinionofflavouringgroupevaluation500fge500rumether
AT zornholger scientificopinionofflavouringgroupevaluation500fge500rumether
AT zugravucorinaaurelia scientificopinionofflavouringgroupevaluation500fge500rumether
AT beckmansundhulla scientificopinionofflavouringgroupevaluation500fge500rumether
AT benigniromualdo scientificopinionofflavouringgroupevaluation500fge500rumether
AT brimerleon scientificopinionofflavouringgroupevaluation500fge500rumether
AT muldergerard scientificopinionofflavouringgroupevaluation500fge500rumether
AT oskarssonagneta scientificopinionofflavouringgroupevaluation500fge500rumether
AT svendsencamilla scientificopinionofflavouringgroupevaluation500fge500rumether
AT martinocarla scientificopinionofflavouringgroupevaluation500fge500rumether
AT menneswim scientificopinionofflavouringgroupevaluation500fge500rumether