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Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to deliver a scientific opinion on the implications for human health of the flavouring rum ether [FL‐no: 21.001] in the Flavouring Group Evaluation 500 (FGE.500), accordi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010020/ https://www.ncbi.nlm.nih.gov/pubmed/32625610 http://dx.doi.org/10.2903/j.efsa.2017.4897 |
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author | Silano, Vittorio Bolognesi, Claudia Castle, Laurence Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Gürtler, Rainer Husøy, Trine Kärenlampi, Sirpa Milana, Maria Rosaria Penninks, André Tavares Poças, Maria de Fátima Smith, Andrew Tlustos, Christina Wölfle, Detlef Zorn, Holger Zugravu, Corina‐Aurelia Beckman Sundh, Ulla Benigni, Romualdo Brimer, Leon Mulder, Gerard Oskarsson, Agneta Svendsen, Camilla Martino, Carla Mennes, Wim |
author_facet | Silano, Vittorio Bolognesi, Claudia Castle, Laurence Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Gürtler, Rainer Husøy, Trine Kärenlampi, Sirpa Milana, Maria Rosaria Penninks, André Tavares Poças, Maria de Fátima Smith, Andrew Tlustos, Christina Wölfle, Detlef Zorn, Holger Zugravu, Corina‐Aurelia Beckman Sundh, Ulla Benigni, Romualdo Brimer, Leon Mulder, Gerard Oskarsson, Agneta Svendsen, Camilla Martino, Carla Mennes, Wim |
collection | PubMed |
description | The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to deliver a scientific opinion on the implications for human health of the flavouring rum ether [FL‐no: 21.001] in the Flavouring Group Evaluation 500 (FGE.500), according to Regulation (EC) No 1331/2008 and Regulation (EC) No 1334/2008 of the European Parliament and of the Council. Rum ether is a complex mixture of volatile substances obtained by distillation of the reaction products of pyroligneous acid and ethyl alcohol under oxidative conditions in the presence of manganese dioxide and sulfuric acid. A total of 84 volatile constituents have been reported by the applicant. It is a colourless liquid with a rum‐like odour and flavour. Its major uses are in the food categories beverages, confectionery and baked goods. The Panel decided to apply a congeneric group‐based approach. The 84 reported constituents were allocated to 12 congeneric groups, based on structural and metabolic similarity. For eight of the congeneric groups, the Panel concluded that there is no safety concern at the intended conditions of use. However, the Panel concluded that substances in congeneric group 1 (ethanol and acetaldehyde) and congeneric group 12 (furan) are carcinogenic and genotoxic. The Panel also identified genotoxicity concerns for substances in congeneric group 3 (3‐pentene‐2‐one). The exposure for congeneric group 10 (ethers of various structures) was above the Threshold of Toxicological Concern (TTC) applicable for this group, but a point of departure or health based guidance value that covers all the substances in this group could not be identified. The Panel concluded that according to the overall strategy for the risk assessment of flavouring substances, the presence of genotoxic substances as process‐derived constituents of rum ether is of safety concern. |
format | Online Article Text |
id | pubmed-7010020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70100202020-07-02 Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether Silano, Vittorio Bolognesi, Claudia Castle, Laurence Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Gürtler, Rainer Husøy, Trine Kärenlampi, Sirpa Milana, Maria Rosaria Penninks, André Tavares Poças, Maria de Fátima Smith, Andrew Tlustos, Christina Wölfle, Detlef Zorn, Holger Zugravu, Corina‐Aurelia Beckman Sundh, Ulla Benigni, Romualdo Brimer, Leon Mulder, Gerard Oskarsson, Agneta Svendsen, Camilla Martino, Carla Mennes, Wim EFSA J Scientific Opinion The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to deliver a scientific opinion on the implications for human health of the flavouring rum ether [FL‐no: 21.001] in the Flavouring Group Evaluation 500 (FGE.500), according to Regulation (EC) No 1331/2008 and Regulation (EC) No 1334/2008 of the European Parliament and of the Council. Rum ether is a complex mixture of volatile substances obtained by distillation of the reaction products of pyroligneous acid and ethyl alcohol under oxidative conditions in the presence of manganese dioxide and sulfuric acid. A total of 84 volatile constituents have been reported by the applicant. It is a colourless liquid with a rum‐like odour and flavour. Its major uses are in the food categories beverages, confectionery and baked goods. The Panel decided to apply a congeneric group‐based approach. The 84 reported constituents were allocated to 12 congeneric groups, based on structural and metabolic similarity. For eight of the congeneric groups, the Panel concluded that there is no safety concern at the intended conditions of use. However, the Panel concluded that substances in congeneric group 1 (ethanol and acetaldehyde) and congeneric group 12 (furan) are carcinogenic and genotoxic. The Panel also identified genotoxicity concerns for substances in congeneric group 3 (3‐pentene‐2‐one). The exposure for congeneric group 10 (ethers of various structures) was above the Threshold of Toxicological Concern (TTC) applicable for this group, but a point of departure or health based guidance value that covers all the substances in this group could not be identified. The Panel concluded that according to the overall strategy for the risk assessment of flavouring substances, the presence of genotoxic substances as process‐derived constituents of rum ether is of safety concern. John Wiley and Sons Inc. 2017-08-24 /pmc/articles/PMC7010020/ /pubmed/32625610 http://dx.doi.org/10.2903/j.efsa.2017.4897 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Silano, Vittorio Bolognesi, Claudia Castle, Laurence Cravedi, Jean‐Pierre Engel, Karl‐Heinz Fowler, Paul Franz, Roland Grob, Konrad Gürtler, Rainer Husøy, Trine Kärenlampi, Sirpa Milana, Maria Rosaria Penninks, André Tavares Poças, Maria de Fátima Smith, Andrew Tlustos, Christina Wölfle, Detlef Zorn, Holger Zugravu, Corina‐Aurelia Beckman Sundh, Ulla Benigni, Romualdo Brimer, Leon Mulder, Gerard Oskarsson, Agneta Svendsen, Camilla Martino, Carla Mennes, Wim Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether |
title | Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether |
title_full | Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether |
title_fullStr | Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether |
title_full_unstemmed | Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether |
title_short | Scientific Opinion of Flavouring Group Evaluation 500 (FGE.500): rum ether |
title_sort | scientific opinion of flavouring group evaluation 500 (fge.500): rum ether |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010020/ https://www.ncbi.nlm.nih.gov/pubmed/32625610 http://dx.doi.org/10.2903/j.efsa.2017.4897 |
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