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Human and animal dietary exposure to T‐2 and HT‐2 toxin

T‐2 toxin (T2) and HT‐2 (HT2) toxin are trichothecenes, which form part of the group of Fusarium mycotoxins. Food and feed samples used to estimate human dietary and animal exposure were reported either as the individual results for T2 and/or, HT2, and/or as the sum of the two. The highest concentra...

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Autores principales: Arcella, Davide, Gergelova, Petra, Innocenti, Matteo Lorenzo, Steinkellner, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010047/
https://www.ncbi.nlm.nih.gov/pubmed/32625633
http://dx.doi.org/10.2903/j.efsa.2017.4972
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author Arcella, Davide
Gergelova, Petra
Innocenti, Matteo Lorenzo
Steinkellner, Hans
author_facet Arcella, Davide
Gergelova, Petra
Innocenti, Matteo Lorenzo
Steinkellner, Hans
collection PubMed
description T‐2 toxin (T2) and HT‐2 (HT2) toxin are trichothecenes, which form part of the group of Fusarium mycotoxins. Food and feed samples used to estimate human dietary and animal exposure were reported either as the individual results for T2 and/or, HT2, and/or as the sum of the two. The highest concentrations were reported in oats and oat‐containing commodities. Very high levels were reported in a small number of data on specific plant‐ and herb‐based dietary supplements. In humans, the mean chronic dietary exposure to the sum of T2 and HT2 was highest in ‘Toddlers’ and ‘Infants’, with maximum upper bound (UB) estimates of 64.8 and 62.9 ng/kg body weight (bw) per day, respectively. The 95th percentile dietary exposure was highest in ‘Infants’ with a maximum UB estimate of 146 ng/kg bw per day. UB estimations were on average fourfold higher than lower bound (LB) estimations. Average acute exposure ranged from a minimum of 13.4 ng/kg bw per day, estimated in ‘Elderly’, up to a maximum of 64.7 ng/kg bw per day estimated in ‘Toddlers’. The highest 95th percentile acute dietary exposure was estimated for a dietary survey within the age class ‘Infants’ (170 ng/kg bw per day). Overall, among processed foods the main contributors were cereal flakes, fine bakery wares and, for acute exposure, also bread and rolls. In the elderly and very elderly, dietary supplements made an important contribution. Exposure to the sum of T2 and HT2 in farm and companion animals varied according to the animal species. Exposures considering mean concentration scenarios varied between 0.03–0.08 (LB–UB) μg/kg bw per day in beef cattle and 1.13–1.47 μg/kg bw per day in milking goats. For high concentration scenarios, exposures varied between 0.12–0.16 μg/kg bw per day and 2.37–2.58μg/kg bw per day in the same species. In the absence of data, potential modified form were not included.
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spelling pubmed-70100472020-07-02 Human and animal dietary exposure to T‐2 and HT‐2 toxin Arcella, Davide Gergelova, Petra Innocenti, Matteo Lorenzo Steinkellner, Hans EFSA J Scientific Reports T‐2 toxin (T2) and HT‐2 (HT2) toxin are trichothecenes, which form part of the group of Fusarium mycotoxins. Food and feed samples used to estimate human dietary and animal exposure were reported either as the individual results for T2 and/or, HT2, and/or as the sum of the two. The highest concentrations were reported in oats and oat‐containing commodities. Very high levels were reported in a small number of data on specific plant‐ and herb‐based dietary supplements. In humans, the mean chronic dietary exposure to the sum of T2 and HT2 was highest in ‘Toddlers’ and ‘Infants’, with maximum upper bound (UB) estimates of 64.8 and 62.9 ng/kg body weight (bw) per day, respectively. The 95th percentile dietary exposure was highest in ‘Infants’ with a maximum UB estimate of 146 ng/kg bw per day. UB estimations were on average fourfold higher than lower bound (LB) estimations. Average acute exposure ranged from a minimum of 13.4 ng/kg bw per day, estimated in ‘Elderly’, up to a maximum of 64.7 ng/kg bw per day estimated in ‘Toddlers’. The highest 95th percentile acute dietary exposure was estimated for a dietary survey within the age class ‘Infants’ (170 ng/kg bw per day). Overall, among processed foods the main contributors were cereal flakes, fine bakery wares and, for acute exposure, also bread and rolls. In the elderly and very elderly, dietary supplements made an important contribution. Exposure to the sum of T2 and HT2 in farm and companion animals varied according to the animal species. Exposures considering mean concentration scenarios varied between 0.03–0.08 (LB–UB) μg/kg bw per day in beef cattle and 1.13–1.47 μg/kg bw per day in milking goats. For high concentration scenarios, exposures varied between 0.12–0.16 μg/kg bw per day and 2.37–2.58μg/kg bw per day in the same species. In the absence of data, potential modified form were not included. John Wiley and Sons Inc. 2017-08-14 /pmc/articles/PMC7010047/ /pubmed/32625633 http://dx.doi.org/10.2903/j.efsa.2017.4972 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Reports
Arcella, Davide
Gergelova, Petra
Innocenti, Matteo Lorenzo
Steinkellner, Hans
Human and animal dietary exposure to T‐2 and HT‐2 toxin
title Human and animal dietary exposure to T‐2 and HT‐2 toxin
title_full Human and animal dietary exposure to T‐2 and HT‐2 toxin
title_fullStr Human and animal dietary exposure to T‐2 and HT‐2 toxin
title_full_unstemmed Human and animal dietary exposure to T‐2 and HT‐2 toxin
title_short Human and animal dietary exposure to T‐2 and HT‐2 toxin
title_sort human and animal dietary exposure to t‐2 and ht‐2 toxin
topic Scientific Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010047/
https://www.ncbi.nlm.nih.gov/pubmed/32625633
http://dx.doi.org/10.2903/j.efsa.2017.4972
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