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Safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 18 compounds belonging to chemical group (CG) 22. They are currently authorised as flavours in...

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Autores principales: Rychen, Guido, Aquilina, Gabriele, Azimonti, Giovanna, Bampidis, Vasileios, Bastos, Maria de Lourdes, Bories, Georges, Cocconcelli, Pier Sandro, Flachowsky, Gerhard, Gropp, Jürgen, Kolar, Boris, Kouba, Maryline, López Puente, Secundino, López‐Alonso, Marta, Mantovani, Alberto, Mayo, Baltasar, Ramos, Fernando, Saarela, Maria, Villa, Roberto Edoardo, Wallace, Robert John, Wester, Pieter, Brantom, Paul, Dusemund, Birgit, Hogstrand, Christer, Van Beelen, Patrick, Westendorf, Johannes, Gregoretti, Lucilla, Manini, Paola, Chesson, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010084/
https://www.ncbi.nlm.nih.gov/pubmed/32625398
http://dx.doi.org/10.2903/j.efsa.2017.4672
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author Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Dusemund, Birgit
Hogstrand, Christer
Van Beelen, Patrick
Westendorf, Johannes
Gregoretti, Lucilla
Manini, Paola
Chesson, Andrew
author_facet Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Dusemund, Birgit
Hogstrand, Christer
Van Beelen, Patrick
Westendorf, Johannes
Gregoretti, Lucilla
Manini, Paola
Chesson, Andrew
collection PubMed
description Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 18 compounds belonging to chemical group (CG) 22. They are currently authorised as flavours in food. The FEEDAP Panel concludes that: cinnamaldehyde [05.014] is safe at the maximum use level of 125 mg/kg complete feed for salmonids, veal calves and dogs, and at 25 mg/kg for the remaining target species; cinnamyl alcohol [02.017], 3‐phenylpropan‐1‐ol [02.031], 3‐(p‐cumenyl)‐2‐methylpropionaldehyde [05.045], α‐methylcinnamaldehyde [05.050], 3‐phenylpropanal [05.080], cinnamic acid [08.022], cinnamyl acetate [09.018], cinnamyl butyrate [09.053], 3‐phenylpropyl isobutyrate [09.428], cinnamyl isovalerate [09.459], cinnamyl isobutyrate [09.470], ethyl cinnamate [09.730], methyl cinnamate [09.740] and isopentyl cinnamate [09.742] are safe at the proposed maximum use level of 5 mg/kg complete feed for all target species; 2‐phenylpropanal [05.038], α‐pentylcinnamaldehyde [05.040] and α‐hexylcinnamaldehyde [05.041] are safe at the proposed maximum dose level of 5 mg/kg complete feed for all target species except cats, for which 1 mg/kg is safe. No safety concern would arise for the consumer from the use of these compounds up to the highest proposed level in feeds. Irritation and sensitisation hazards for skin and irritation for eye are recognised for the majority of the compounds under application. Respiratory exposure may also be hazardous. For the majority of the compounds belonging to CG 22, the maximum proposed use levels are considered safe for the environment. For α‐pentylcinnamaldehyde and α‐hexylcinnamaldehyde, a use level up to 0.1 mg/kg feed would not cause a risk for the terrestrial and fresh water compartments. Because all the compounds under assessment are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary.
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spelling pubmed-70100842020-07-02 Safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López Puente, Secundino López‐Alonso, Marta Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brantom, Paul Dusemund, Birgit Hogstrand, Christer Van Beelen, Patrick Westendorf, Johannes Gregoretti, Lucilla Manini, Paola Chesson, Andrew EFSA J Scientific Opinion Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 18 compounds belonging to chemical group (CG) 22. They are currently authorised as flavours in food. The FEEDAP Panel concludes that: cinnamaldehyde [05.014] is safe at the maximum use level of 125 mg/kg complete feed for salmonids, veal calves and dogs, and at 25 mg/kg for the remaining target species; cinnamyl alcohol [02.017], 3‐phenylpropan‐1‐ol [02.031], 3‐(p‐cumenyl)‐2‐methylpropionaldehyde [05.045], α‐methylcinnamaldehyde [05.050], 3‐phenylpropanal [05.080], cinnamic acid [08.022], cinnamyl acetate [09.018], cinnamyl butyrate [09.053], 3‐phenylpropyl isobutyrate [09.428], cinnamyl isovalerate [09.459], cinnamyl isobutyrate [09.470], ethyl cinnamate [09.730], methyl cinnamate [09.740] and isopentyl cinnamate [09.742] are safe at the proposed maximum use level of 5 mg/kg complete feed for all target species; 2‐phenylpropanal [05.038], α‐pentylcinnamaldehyde [05.040] and α‐hexylcinnamaldehyde [05.041] are safe at the proposed maximum dose level of 5 mg/kg complete feed for all target species except cats, for which 1 mg/kg is safe. No safety concern would arise for the consumer from the use of these compounds up to the highest proposed level in feeds. Irritation and sensitisation hazards for skin and irritation for eye are recognised for the majority of the compounds under application. Respiratory exposure may also be hazardous. For the majority of the compounds belonging to CG 22, the maximum proposed use levels are considered safe for the environment. For α‐pentylcinnamaldehyde and α‐hexylcinnamaldehyde, a use level up to 0.1 mg/kg feed would not cause a risk for the terrestrial and fresh water compartments. Because all the compounds under assessment are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary. John Wiley and Sons Inc. 2017-02-01 /pmc/articles/PMC7010084/ /pubmed/32625398 http://dx.doi.org/10.2903/j.efsa.2017.4672 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Rychen, Guido
Aquilina, Gabriele
Azimonti, Giovanna
Bampidis, Vasileios
Bastos, Maria de Lourdes
Bories, Georges
Cocconcelli, Pier Sandro
Flachowsky, Gerhard
Gropp, Jürgen
Kolar, Boris
Kouba, Maryline
López Puente, Secundino
López‐Alonso, Marta
Mantovani, Alberto
Mayo, Baltasar
Ramos, Fernando
Saarela, Maria
Villa, Roberto Edoardo
Wallace, Robert John
Wester, Pieter
Brantom, Paul
Dusemund, Birgit
Hogstrand, Christer
Van Beelen, Patrick
Westendorf, Johannes
Gregoretti, Lucilla
Manini, Paola
Chesson, Andrew
Safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species
title Safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species
title_full Safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species
title_fullStr Safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species
title_full_unstemmed Safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species
title_short Safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species
title_sort safety and efficacy of aryl‐substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010084/
https://www.ncbi.nlm.nih.gov/pubmed/32625398
http://dx.doi.org/10.2903/j.efsa.2017.4672
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