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Safety and efficacy of Lactobacillus casei DSM 28872 as a silage additive for all animal species
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed was asked to deliver a scientific opinion on the safety and efficacy of a strain of Lactobacillus casei when used as a technological additive intended to improve ensiling at a prop...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010089/ https://www.ncbi.nlm.nih.gov/pubmed/32625426 http://dx.doi.org/10.2903/j.efsa.2017.4703 |
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author | Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Ramos, Fernando Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brozzi, Rosella Saarela, Maria |
author_facet | Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Ramos, Fernando Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brozzi, Rosella Saarela, Maria |
collection | PubMed |
description | Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed was asked to deliver a scientific opinion on the safety and efficacy of a strain of Lactobacillus casei when used as a technological additive intended to improve ensiling at a proposed application rate of 1 × 10(8) CFU (when used alone) or 5 × 10(7) CFU (when used in combination) kg/fresh matter. The species L. casei is considered by EFSA to be suitable for the qualified presumption of safety approach to safety assessment and not to require specific demonstration of safety other than the absence of resistance to antibiotics of human and veterinary significance. As the identity of the strain was clearly established and as no antibiotic resistance was detected, the use of the strain in the production of silage is presumed safe for livestock species, consumers of products from animals fed treated silage and the environment. In the absence of data, no conclusion can be drawn on the skin and eye irritancy of the additive. The additive should be considered to have the potential to be a respiratory sensitiser. Five studies with laboratory‐scale silos were made using forage of differing water‐soluble carbohydrate content. Replicate silos containing forages treated at the proposed application rate were compared to identical silos containing the same but untreated forage. The mini‐silos were stored for 90 days at 20–24°C. At the end of the ensiling period, the content of the silos was analysed and dry matter losses determined. Results showed that the L. casei strain applied at a minimum dose of 5 × 10(7) CFU/kg has the potential to improve the production of silage from easy and moderately difficult to ensile forage species by reducing dry matter loss and enhancing protein preservation. |
format | Online Article Text |
id | pubmed-7010089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70100892020-07-02 Safety and efficacy of Lactobacillus casei DSM 28872 as a silage additive for all animal species Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Ramos, Fernando Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brozzi, Rosella Saarela, Maria EFSA J Scientific Opinion Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed was asked to deliver a scientific opinion on the safety and efficacy of a strain of Lactobacillus casei when used as a technological additive intended to improve ensiling at a proposed application rate of 1 × 10(8) CFU (when used alone) or 5 × 10(7) CFU (when used in combination) kg/fresh matter. The species L. casei is considered by EFSA to be suitable for the qualified presumption of safety approach to safety assessment and not to require specific demonstration of safety other than the absence of resistance to antibiotics of human and veterinary significance. As the identity of the strain was clearly established and as no antibiotic resistance was detected, the use of the strain in the production of silage is presumed safe for livestock species, consumers of products from animals fed treated silage and the environment. In the absence of data, no conclusion can be drawn on the skin and eye irritancy of the additive. The additive should be considered to have the potential to be a respiratory sensitiser. Five studies with laboratory‐scale silos were made using forage of differing water‐soluble carbohydrate content. Replicate silos containing forages treated at the proposed application rate were compared to identical silos containing the same but untreated forage. The mini‐silos were stored for 90 days at 20–24°C. At the end of the ensiling period, the content of the silos was analysed and dry matter losses determined. Results showed that the L. casei strain applied at a minimum dose of 5 × 10(7) CFU/kg has the potential to improve the production of silage from easy and moderately difficult to ensile forage species by reducing dry matter loss and enhancing protein preservation. John Wiley and Sons Inc. 2017-03-02 /pmc/articles/PMC7010089/ /pubmed/32625426 http://dx.doi.org/10.2903/j.efsa.2017.4703 Text en © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Mantovani, Alberto Ramos, Fernando Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brozzi, Rosella Saarela, Maria Safety and efficacy of Lactobacillus casei DSM 28872 as a silage additive for all animal species |
title | Safety and efficacy of Lactobacillus casei
DSM 28872 as a silage additive for all animal species |
title_full | Safety and efficacy of Lactobacillus casei
DSM 28872 as a silage additive for all animal species |
title_fullStr | Safety and efficacy of Lactobacillus casei
DSM 28872 as a silage additive for all animal species |
title_full_unstemmed | Safety and efficacy of Lactobacillus casei
DSM 28872 as a silage additive for all animal species |
title_short | Safety and efficacy of Lactobacillus casei
DSM 28872 as a silage additive for all animal species |
title_sort | safety and efficacy of lactobacillus casei
dsm 28872 as a silage additive for all animal species |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010089/ https://www.ncbi.nlm.nih.gov/pubmed/32625426 http://dx.doi.org/10.2903/j.efsa.2017.4703 |
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