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Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis

CRK and CRKL (CRK-like) encode adapter proteins with similar biochemical properties. Here, we show that a 50% reduction of the family-combined dosage generates developmental defects, including aspects of DiGeorge/del22q11 syndrome in mice. Like the mouse homologs of two 22q11.21 genes CRKL and TBX1,...

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Detalles Bibliográficos
Autores principales:	Imamoto, Akira, Ki, Sewon, Li, Leiming, Iwamoto, Kazunari, Maruthamuthu, Venkat, Devany, John, Lu, Ocean, Kanazawa, Tomomi, Zhang, Suxiang, Yamada, Takuji, Hirayama, Akiyoshi, Fukuda, Shinji, Suzuki, Yutaka, Okada, Mariko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010317/ https://www.ncbi.nlm.nih.gov/pubmed/32041892 http://dx.doi.org/10.26508/lsa.201900635

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