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Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children

INTRODUCTION: Animal studies have shown that male but not female offspring exposed to maternal obesity have abnormal hippocampal development. Similar sex differences were observed in animal models of developmental programming by prenatal stress or maternal diabetes. We aimed to translate this work i...

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Autores principales: Alves, Jasmin M., Luo, Shan, Chow, Ting, Herting, Megan, Xiang, Anny H., Page, Kathleen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010582/
https://www.ncbi.nlm.nih.gov/pubmed/31903710
http://dx.doi.org/10.1002/brb3.1522
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author Alves, Jasmin M.
Luo, Shan
Chow, Ting
Herting, Megan
Xiang, Anny H.
Page, Kathleen A.
author_facet Alves, Jasmin M.
Luo, Shan
Chow, Ting
Herting, Megan
Xiang, Anny H.
Page, Kathleen A.
author_sort Alves, Jasmin M.
collection PubMed
description INTRODUCTION: Animal studies have shown that male but not female offspring exposed to maternal obesity have abnormal hippocampal development. Similar sex differences were observed in animal models of developmental programming by prenatal stress or maternal diabetes. We aimed to translate this work into humans by examining sex‐specific effects of exposure to maternal obesity on hippocampal volume in children. METHODS: Eighty‐eight children (37 boys and 51 girls) aged 7–11 years completed the study. Maternal prepregnancy body mass index (BMI) was obtained from electronic medical records. A high‐resolution anatomical scan was performed using a 3‐Tesla magnetic resonance imaging (MRI) scanner. Total hippocampal volume and hippocampal subfield volumes were analyzed using FreeSurfer 6.0. Linear regression was used to investigate sex differences in relationships between maternal prepregnancy BMI and child hippocampal volume. RESULTS: Maternal prepregnancy BMI ranged from 19.0 to 50.4 kg/m(2). We observed a significant interaction between maternal prepregnancy BMI and sex on total hippocampal volume (p < .001) such that boys (r = −.39, p = .018) but not girls (r = .11, p = .45) had a significant negative relationship between maternal prepregnancy BMI and total hippocampal volume. This relationship in boys remained significant after adjusting for child and maternal covariates (β = −126.98, p = .012). The sex interactions with prepregnancy BMI were consistently observed in hippocampal subfields CA1 (p = .008), CA2/3 (p = .016), CA4 (p = .002), dentate gyrus (p < .001), and subiculum (p < .001). CONCLUSIONS: Our results support findings in animal models and suggest that boys may be more vulnerable to the adverse effects of exposure to maternal obesity on hippocampal development than girls.
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spelling pubmed-70105822020-02-13 Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children Alves, Jasmin M. Luo, Shan Chow, Ting Herting, Megan Xiang, Anny H. Page, Kathleen A. Brain Behav Original Research INTRODUCTION: Animal studies have shown that male but not female offspring exposed to maternal obesity have abnormal hippocampal development. Similar sex differences were observed in animal models of developmental programming by prenatal stress or maternal diabetes. We aimed to translate this work into humans by examining sex‐specific effects of exposure to maternal obesity on hippocampal volume in children. METHODS: Eighty‐eight children (37 boys and 51 girls) aged 7–11 years completed the study. Maternal prepregnancy body mass index (BMI) was obtained from electronic medical records. A high‐resolution anatomical scan was performed using a 3‐Tesla magnetic resonance imaging (MRI) scanner. Total hippocampal volume and hippocampal subfield volumes were analyzed using FreeSurfer 6.0. Linear regression was used to investigate sex differences in relationships between maternal prepregnancy BMI and child hippocampal volume. RESULTS: Maternal prepregnancy BMI ranged from 19.0 to 50.4 kg/m(2). We observed a significant interaction between maternal prepregnancy BMI and sex on total hippocampal volume (p < .001) such that boys (r = −.39, p = .018) but not girls (r = .11, p = .45) had a significant negative relationship between maternal prepregnancy BMI and total hippocampal volume. This relationship in boys remained significant after adjusting for child and maternal covariates (β = −126.98, p = .012). The sex interactions with prepregnancy BMI were consistently observed in hippocampal subfields CA1 (p = .008), CA2/3 (p = .016), CA4 (p = .002), dentate gyrus (p < .001), and subiculum (p < .001). CONCLUSIONS: Our results support findings in animal models and suggest that boys may be more vulnerable to the adverse effects of exposure to maternal obesity on hippocampal development than girls. John Wiley and Sons Inc. 2020-01-05 /pmc/articles/PMC7010582/ /pubmed/31903710 http://dx.doi.org/10.1002/brb3.1522 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Alves, Jasmin M.
Luo, Shan
Chow, Ting
Herting, Megan
Xiang, Anny H.
Page, Kathleen A.
Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children
title Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children
title_full Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children
title_fullStr Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children
title_full_unstemmed Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children
title_short Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children
title_sort sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010582/
https://www.ncbi.nlm.nih.gov/pubmed/31903710
http://dx.doi.org/10.1002/brb3.1522
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