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Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort

SUMMARY: In smokers and former smokers from the ECLIPSE cohort, there is an association between prevalent vertebral fractures (VFs) and coronary artery calcification (CAC). Chest CT scans provide the opportunity to evaluate VFs and CAC, which are potentially important comorbidities, each of which is...

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Autores principales: van Dort, M. J., Driessen, J. H. M., Geusens, P., Romme, E. A. P. M., Smeenk, F. W. J. M., Rahel, B. M., Eisman, J. A., Wouters, E. F. M., van den Bergh, J. P. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010611/
https://www.ncbi.nlm.nih.gov/pubmed/31768590
http://dx.doi.org/10.1007/s00198-019-05218-w
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author van Dort, M. J.
Driessen, J. H. M.
Geusens, P.
Romme, E. A. P. M.
Smeenk, F. W. J. M.
Rahel, B. M.
Eisman, J. A.
Wouters, E. F. M.
van den Bergh, J. P. W.
author_facet van Dort, M. J.
Driessen, J. H. M.
Geusens, P.
Romme, E. A. P. M.
Smeenk, F. W. J. M.
Rahel, B. M.
Eisman, J. A.
Wouters, E. F. M.
van den Bergh, J. P. W.
author_sort van Dort, M. J.
collection PubMed
description SUMMARY: In smokers and former smokers from the ECLIPSE cohort, there is an association between prevalent vertebral fractures (VFs) and coronary artery calcification (CAC). Chest CT scans provide the opportunity to evaluate VFs and CAC, which are potentially important comorbidities, each of which is amenable to effective interventions. INTRODUCTION: Prevalence of VFs among smokers and patients with chronic obstructive pulmonary disease (COPD) is high, and an association between CAC and osteoporosis has been described. We investigated the associations between VFs and CAC (expressed in Agatston score) in (former) smokers. METHODS: Current and former smokers from the ECLIPSE study (designed to determine underlying COPD progression mechanisms) were studied. Baseline Agatston score (zero (0), medium (1–400), or high (> 400)), baseline bone attenuation (BA), and prevalent and incident VFs (vertebrae T(1)–L(1)) were assessed on CT. RESULTS: A total of 586 subjects were included (mean age 59.8 ± 8.3; 62.3% men; 70.1% with COPD; 21.0% with prevalent VFs; 196 with zero, 266 with medium, and 124 with high Agatston score). Of these, 23.4% suffered incident VFs within 3 years. In multivariate models, prevalent VFs were associated with medium (1.83 [95% CI 1.01–3.30]) and with high (OR = 3.06 [1.45–6.47]) Agatston score. After adjustment for BA, prevalent VFs were still associated with high (OR = 2.47 [1.13–5.40]), but not significantly with medium Agatston score (OR = 1.57 [0.85–2.88]). Similarly, after adjustment for BA, high (OR = 2.06 [1.02–4.13]) but not medium Agatston score (OR = 1.61 [0.88–2.94]) was associated with prevalent VFs. Agatston score at baseline was not associated with short-term VF incidence. CONCLUSION: In (former) smokers, there was an association between prevalent VFs and Agatston score. Chest CT scans provide the opportunity to also evaluate for VFs and CAC, which are potentially important comorbidities, each of which is amenable to effective interventions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00198-019-05218-w) contains supplementary material, which is available to authorized users.
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spelling pubmed-70106112020-02-24 Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort van Dort, M. J. Driessen, J. H. M. Geusens, P. Romme, E. A. P. M. Smeenk, F. W. J. M. Rahel, B. M. Eisman, J. A. Wouters, E. F. M. van den Bergh, J. P. W. Osteoporos Int Original Article SUMMARY: In smokers and former smokers from the ECLIPSE cohort, there is an association between prevalent vertebral fractures (VFs) and coronary artery calcification (CAC). Chest CT scans provide the opportunity to evaluate VFs and CAC, which are potentially important comorbidities, each of which is amenable to effective interventions. INTRODUCTION: Prevalence of VFs among smokers and patients with chronic obstructive pulmonary disease (COPD) is high, and an association between CAC and osteoporosis has been described. We investigated the associations between VFs and CAC (expressed in Agatston score) in (former) smokers. METHODS: Current and former smokers from the ECLIPSE study (designed to determine underlying COPD progression mechanisms) were studied. Baseline Agatston score (zero (0), medium (1–400), or high (> 400)), baseline bone attenuation (BA), and prevalent and incident VFs (vertebrae T(1)–L(1)) were assessed on CT. RESULTS: A total of 586 subjects were included (mean age 59.8 ± 8.3; 62.3% men; 70.1% with COPD; 21.0% with prevalent VFs; 196 with zero, 266 with medium, and 124 with high Agatston score). Of these, 23.4% suffered incident VFs within 3 years. In multivariate models, prevalent VFs were associated with medium (1.83 [95% CI 1.01–3.30]) and with high (OR = 3.06 [1.45–6.47]) Agatston score. After adjustment for BA, prevalent VFs were still associated with high (OR = 2.47 [1.13–5.40]), but not significantly with medium Agatston score (OR = 1.57 [0.85–2.88]). Similarly, after adjustment for BA, high (OR = 2.06 [1.02–4.13]) but not medium Agatston score (OR = 1.61 [0.88–2.94]) was associated with prevalent VFs. Agatston score at baseline was not associated with short-term VF incidence. CONCLUSION: In (former) smokers, there was an association between prevalent VFs and Agatston score. Chest CT scans provide the opportunity to also evaluate for VFs and CAC, which are potentially important comorbidities, each of which is amenable to effective interventions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00198-019-05218-w) contains supplementary material, which is available to authorized users. Springer London 2019-11-25 2020 /pmc/articles/PMC7010611/ /pubmed/31768590 http://dx.doi.org/10.1007/s00198-019-05218-w Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
van Dort, M. J.
Driessen, J. H. M.
Geusens, P.
Romme, E. A. P. M.
Smeenk, F. W. J. M.
Rahel, B. M.
Eisman, J. A.
Wouters, E. F. M.
van den Bergh, J. P. W.
Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort
title Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort
title_full Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort
title_fullStr Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort
title_full_unstemmed Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort
title_short Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort
title_sort association between vertebral fractures and coronary artery calcification in current and former smokers in the eclipse cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010611/
https://www.ncbi.nlm.nih.gov/pubmed/31768590
http://dx.doi.org/10.1007/s00198-019-05218-w
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