The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader–Willi Syndromes

Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n ...

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Detalles Bibliográficos
Autores principales: Royston, R., Oliver, C., Howlin, P., Dosse, A., Armitage, P., Moss, J., Waite, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010621/
https://www.ncbi.nlm.nih.gov/pubmed/31802317
http://dx.doi.org/10.1007/s10803-019-04317-1
Descripción
Sumario:Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader–Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12–57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10803-019-04317-1) contains supplementary material, which is available to authorized users.

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