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Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease

Sex differences in coronary artery disease (CAD) are well established, with women presenting with non-obstructive CAD more often than men do. However, recent evidence has identified coronary microvascular dysfunction as the underlying cause for cardiac complaints, yet sex-specific prevalence numbers...

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Autores principales: Groepenhoff, Floor, Bots, Sophie H., Kessler, Elise L., Sickinghe, Ariane A., Eikendal, Anouk L. M., Leiner, Tim, den Ruijter, Hester M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010630/
https://www.ncbi.nlm.nih.gov/pubmed/31471830
http://dx.doi.org/10.1007/s12265-019-09906-0
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author Groepenhoff, Floor
Bots, Sophie H.
Kessler, Elise L.
Sickinghe, Ariane A.
Eikendal, Anouk L. M.
Leiner, Tim
den Ruijter, Hester M.
author_facet Groepenhoff, Floor
Bots, Sophie H.
Kessler, Elise L.
Sickinghe, Ariane A.
Eikendal, Anouk L. M.
Leiner, Tim
den Ruijter, Hester M.
author_sort Groepenhoff, Floor
collection PubMed
description Sex differences in coronary artery disease (CAD) are well established, with women presenting with non-obstructive CAD more often than men do. However, recent evidence has identified coronary microvascular dysfunction as the underlying cause for cardiac complaints, yet sex-specific prevalence numbers are inconclusive. This review summarises known sex-specific aspects in the pathophysiology of both macro- and microvascular dysfunction and identifies currently existing knowledge gaps. In addition, this review describes current diagnostic approaches and whether these should take underlying sex differences into account by, for example, using different techniques or cut-off values for women and men. Future research into both innovation of imaging techniques and perfusion-related sex differences is needed to fill evidence gaps and enable the implementation of the available knowledge in daily clinical practice.
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spelling pubmed-70106302020-02-24 Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease Groepenhoff, Floor Bots, Sophie H. Kessler, Elise L. Sickinghe, Ariane A. Eikendal, Anouk L. M. Leiner, Tim den Ruijter, Hester M. J Cardiovasc Transl Res Review Article Sex differences in coronary artery disease (CAD) are well established, with women presenting with non-obstructive CAD more often than men do. However, recent evidence has identified coronary microvascular dysfunction as the underlying cause for cardiac complaints, yet sex-specific prevalence numbers are inconclusive. This review summarises known sex-specific aspects in the pathophysiology of both macro- and microvascular dysfunction and identifies currently existing knowledge gaps. In addition, this review describes current diagnostic approaches and whether these should take underlying sex differences into account by, for example, using different techniques or cut-off values for women and men. Future research into both innovation of imaging techniques and perfusion-related sex differences is needed to fill evidence gaps and enable the implementation of the available knowledge in daily clinical practice. Springer US 2019-08-30 2020 /pmc/articles/PMC7010630/ /pubmed/31471830 http://dx.doi.org/10.1007/s12265-019-09906-0 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Groepenhoff, Floor
Bots, Sophie H.
Kessler, Elise L.
Sickinghe, Ariane A.
Eikendal, Anouk L. M.
Leiner, Tim
den Ruijter, Hester M.
Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease
title Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease
title_full Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease
title_fullStr Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease
title_full_unstemmed Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease
title_short Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease
title_sort sex-specific aspects in the pathophysiology and imaging of coronary macro- and microvascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010630/
https://www.ncbi.nlm.nih.gov/pubmed/31471830
http://dx.doi.org/10.1007/s12265-019-09906-0
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