Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition

DNA alkylation damage is repaired by base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG). Despite its role in DNA repair, AAG-initiated BER promotes cytotoxicity in a process dependent on poly (ADP-ribose) polymerase-1 (PARP-1); a NAD(+)-consuming enzyme activated by strand br...

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Detalles Bibliográficos
Autores principales: Alhumaydhi, Fahad A., de O. Lopes, Debora, Bordin, Diana L., Aljohani, Abdullah S. M., Lloyd, Cameron B., McNicholas, Michael D., Milano, Larissa, Charlier, Clara F., Villela, Izabel, Henriques, João Antonio P., Plant, Kathryn E., Elliott, Ruan M., Meira, Lisiane B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010680/
https://www.ncbi.nlm.nih.gov/pubmed/32042007
http://dx.doi.org/10.1038/s41598-020-59072-6

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