Endoplasmic reticulum stress promotes inflammation-mediated proteolytic activity at the ocular surface

A growing body of evidence implicates endoplasmic reticulum (ER) stress in the pathogenesis of chronic inflammatory and autoimmune disorders. Here, we demonstrate that the proinflammatory cytokine TNFα stimulates matrix metalloproteinase 9 (MMP9) at the ocular surface through a c-Fos-dependent mecha...

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Detalles Bibliográficos
Autores principales: Woodward, Ashley M., Di Zazzo, Antonio, Bonini, Stefano, Argüeso, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010695/
https://www.ncbi.nlm.nih.gov/pubmed/32042069
http://dx.doi.org/10.1038/s41598-020-59237-3

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