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Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep

Small ruminant lentiviruses (SRLVs) are found in sheep in Germany and Iran. SRLVs have been classified into four genotypes: A–C and E. Genotype A has been subdivided into 20 subtypes. Previous studies suggested that, first, the ancestors of genotype A are those SRLVs found in Turkey, second, the evo...

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Autores principales: Molaee, Vahid, Bazzucchi, Moira, De Mia, Gian Mario, Otarod, Vahid, Abdollahi, Darab, Rosati, Sergio, Lühken, Gesine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010740/
https://www.ncbi.nlm.nih.gov/pubmed/32042070
http://dx.doi.org/10.1038/s41598-020-58990-9
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author Molaee, Vahid
Bazzucchi, Moira
De Mia, Gian Mario
Otarod, Vahid
Abdollahi, Darab
Rosati, Sergio
Lühken, Gesine
author_facet Molaee, Vahid
Bazzucchi, Moira
De Mia, Gian Mario
Otarod, Vahid
Abdollahi, Darab
Rosati, Sergio
Lühken, Gesine
author_sort Molaee, Vahid
collection PubMed
description Small ruminant lentiviruses (SRLVs) are found in sheep in Germany and Iran. SRLVs have been classified into four genotypes: A–C and E. Genotype A has been subdivided into 20 subtypes. Previous studies suggested that, first, the ancestors of genotype A are those SRLVs found in Turkey, second, the evolution of SRLVs is related to the domestication process, and, third, SRLV infection was first observed in sheep in Iceland and the source of that infection was a flock imported from Germany. This study generated, for the first time, partial SRLV sequence data from German and Iranian sheep, enhancing our knowledge of the genetic and evolutionary relationships of SRLVs, and their associations with the domestication process. Based on 54 SRLV sequences from German and Iranian sheep, our results reveal: (1) SRLV subtypes A4, A5, A11, A16 and A21 (new) are found in German sheep and A22 (new) in Iranian sheep. (2) Genotype A has potentially an additional ancestor (A22), found in Iran, Lebanon and Jordan. (3) Subtype A22 is likely an old version of SRLVs. (4) The transmission routes of some SRLVs are compatible with domestication pathways. (5) This study found no evidence of Icelandic subtype A1 in German sheep.
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spelling pubmed-70107402020-02-21 Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep Molaee, Vahid Bazzucchi, Moira De Mia, Gian Mario Otarod, Vahid Abdollahi, Darab Rosati, Sergio Lühken, Gesine Sci Rep Article Small ruminant lentiviruses (SRLVs) are found in sheep in Germany and Iran. SRLVs have been classified into four genotypes: A–C and E. Genotype A has been subdivided into 20 subtypes. Previous studies suggested that, first, the ancestors of genotype A are those SRLVs found in Turkey, second, the evolution of SRLVs is related to the domestication process, and, third, SRLV infection was first observed in sheep in Iceland and the source of that infection was a flock imported from Germany. This study generated, for the first time, partial SRLV sequence data from German and Iranian sheep, enhancing our knowledge of the genetic and evolutionary relationships of SRLVs, and their associations with the domestication process. Based on 54 SRLV sequences from German and Iranian sheep, our results reveal: (1) SRLV subtypes A4, A5, A11, A16 and A21 (new) are found in German sheep and A22 (new) in Iranian sheep. (2) Genotype A has potentially an additional ancestor (A22), found in Iran, Lebanon and Jordan. (3) Subtype A22 is likely an old version of SRLVs. (4) The transmission routes of some SRLVs are compatible with domestication pathways. (5) This study found no evidence of Icelandic subtype A1 in German sheep. Nature Publishing Group UK 2020-02-10 /pmc/articles/PMC7010740/ /pubmed/32042070 http://dx.doi.org/10.1038/s41598-020-58990-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Molaee, Vahid
Bazzucchi, Moira
De Mia, Gian Mario
Otarod, Vahid
Abdollahi, Darab
Rosati, Sergio
Lühken, Gesine
Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep
title Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep
title_full Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep
title_fullStr Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep
title_full_unstemmed Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep
title_short Phylogenetic analysis of small ruminant lentiviruses in Germany and Iran suggests their expansion with domestic sheep
title_sort phylogenetic analysis of small ruminant lentiviruses in germany and iran suggests their expansion with domestic sheep
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010740/
https://www.ncbi.nlm.nih.gov/pubmed/32042070
http://dx.doi.org/10.1038/s41598-020-58990-9
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